Social Security Compassionate Allowances Conditions List
Author: Ian C. Langtree - Writer/Editor for Disabled World (DW)
Published: 24 Feb 2009 - Updated: 1 Oct 2026
Publication Details: Peer-Reviewed | Informative
Table of Contents:
Synopsis - Definition - Overview - FAQs - Insights, Updates - Related Content
Synopsis
This information sets out the complete alphabetical list of medical conditions recognized under the Social Security Administration's Compassionate Allowances (CAL) program, a peer-reviewed reference covering the aggressive cancers, adult brain disorders, and rare genetic and childhood diseases that the agency treats as clearly meeting its disability standards. It explains how a claim involving a listed diagnosis is identified electronically and can be decided in as little as ten days on limited medical evidence, rather than the months or years a standard claim may take. Because the list follows the SSA's own published conditions, including the specific stages and forms of each illness that qualify, it is a practical reference for people with disabilities, seniors, family caregivers, and advocates who need to confirm quickly whether a diagnosis is covered and how to word an application so it is expedited.
At a Glance
- 1 - Compassionate Allowances (CAL) apply to SSDI, and SSI claims.
- 2 - Compassionate Allowances is not separate from the Social Security Disability Insurance or Supplemental Security Income programs.
- 3 - If you have medical documentation to prove that you have one of the qualifying conditions, your initial claim will automatically be flagged by the SSA and processed much quicker.
- 4 - Compassionate allowances quickly identify diseases and other medical conditions that invariably qualify under the Listing of Impairments based on minimal objective medical information.
- 5 - If your disabling condition is on the Social Security disability compassionate allowances list, you will want to ensure that your application for Social Security disability benefits clearly states this.
- 6 - The U.S. Social Security Administration has held seven Compassionate Allowances public outreach hearings. The hearings were on rare diseases, cancers, traumatic brain injury (TBI) and stroke, early-onset Alzheimer's disease and related dementias, schizophrenia, cardiovascular disease, multiple organ transplants, and autoimmune diseases.
Topic Definition
- Compassionate Allowances (CAL)
Compassionate Allowances is a Social Security Administration initiative that identifies disability claims involving diseases and medical conditions so severe that they meet the agency's definition of disability on the diagnosis alone. Rather than creating a separate benefit, it works as a screening and prioritizing step within the Social Security Disability Insurance and Supplemental Security Income programs, using software to flag applications that name a listed condition. Once the diagnosis is confirmed with basic objective medical evidence, such as a pathology report or genetic test, the claim moves ahead of the normal queue and can be decided in days or weeks. The list is made up mainly of certain cancers, adult brain disorders, and rare disorders affecting children, and it is revised periodically as new conditions are reviewed and added.
Overview
Alphabetical List of Compassionate Allowance Health Conditions
Numbers
- 1p36 Deletion Syndrome
A
- Acute Leukemia
- Adenylosuccinate Lyase Deficiency - Neonatal Form and Type 1
- Adrenal Cancer - with distant metastases or inoperable, unresectable or recurrent
- Adult Heart Transplant Wait List - Status Levels 1-4
- Adult Non-Hodgkin Lymphoma
- Adult Onset Huntington Disease
- Aicardi Syndrome
- Aicardi-Goutieres Syndrome
- Alexander Disease (ALX) - Neonatal and Infantile
- Allan-Herndon-Dudley Syndrome
- Alobar Holoprosencephaly
- Alpers Disease
- Alpha Mannosidosis
- ALS/Parkinsonism Dementia Complex
- Alstrom Syndrome
- Alveolar Soft Part Sarcoma
- Amegakaryocytic Thrombocytopenia
- Amyotrophic Lateral Sclerosis (ALS)
- Anaplastic Adrenal Cancer - with distant metastases or inoperable, unresectable or recurrent
- Anaplastic Ependymoma
- Angelman Syndrome
- Angioimmunoblastic T-cell Lymphoma
- Angiosarcoma
- Aortic Atresia
- Aplastic Anemia
- Astrocytoma - Grade III and IV
- Ataxia Spinocerebellar
- Ataxia Telangiectasia
- Atypical Teratoid/Rhabdoid Tumor
- Au-Kline Syndrome
B
- Bainbridge-Ropers Syndrome
- Baraitser-Winter Syndrome
- Batten Disease
- Beare-Stevenson Cutis Gyrata Syndrome
- Beta Thalassemia Major
- Bilateral Anophthalmia
- Bilateral Optic Atrophy - Infantile
- Bilateral Retinoblastoma
- Bladder Cancer - with distant metastases or inoperable or unresectable
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Bohring-Opitz Syndrome
- Bone Cancer - with distant metastases or inoperable or unresectable
- Breast Cancer - with distant metastases or inoperable or unresectable
C
- Canavan Disease (CD)
- Carcinoma of Unknown Primary Site
- Calciphylaxis
- Carey-Fineman-Ziter Syndrome
- CASK-Related Gene Disorders
- Caudal Regression Syndrome - Types III and IV
- CDKL5 Deficiency Disorder
- Cerebro Oculo Facio Skeletal (COFS) Syndrome
- Cerebrotendinous Xanthomatosis
- Charlevoix Saguenay Spastic Ataxia (ARSACS)
- Child Heart Transplant Wait List - Status Levels 1A/1B
- Child Neuroblastoma
- Child Non-Hodgkin Lymphoma
- Child T-Cell Lymphoblastic Lymphoma
- Cholangiocarcinoma
- Chondrosarcoma with multimodal therapy
- Choroid Plexus Carcinoma
- Chronic Idiopathic Intestinal Pseudo Obstruction
- Chronic Myelogenous Leukemia (CML) - Blast Phase
- CIC-rearranged Sarcoma
- Coffin-Lowry Syndrome
- Congenital Lymphedema
- Congenital Myotonic Dystrophy
- Congenital Zika Syndrome
- Cornelia de Lange Syndrome-Classic Form
- Corticobasal Degeneration
- Costello Syndrome
- Creutzfeldt-Jakob Disease (CJD) - Adult
- Cri du Chat Syndrome
D
- Degos Disease
- DeSanctis Cacchione Syndrome
- Desmoplastic Mesothelioma
- Desmoplastic Small Round Cell Tumors
- Dravet Syndrome
- Duchenne Muscular Dystrophy - Adult
E
- Early-Onset Alzheimer's Disease
- Edwards Syndrome
- Eisenmenger Syndrome
- Endometrial Stromal Sarcoma
- Endomyocardial Fibrosis
- Ependymoblastoma (Child Brain Tumor)
- Erdheim Chester Disease
- Esophageal Cancer
- Esthesioneuroblastoma
- Ewings Sarcoma
F
- Farber's Disease (FD) - Infantile
- Fatal Familial Insomnia
- Fibrodysplasia Ossificans Progressiva
- Fibrolamellar Cancer
- Follicular Dendritic Cell Sarcoma with metastases
- FOXG1 Syndrome
- Friedreichs Ataxia (FRDA)
- Frontotemporal Dementia (FTD), Picks Disease - Type A - Adult
- Fryns Syndrome
- Fucosidosis - Type 1
- Fukuyama Congenital Muscular Dystrophy
- Fulminant Giant Cell Myocarditis
G
- Galactosialidosis - Early Infantile Type
- Gallbladder Cancer
- Gaucher Disease (GD) - Type 2
- Gerstmann-Straussler-Scheinker Disease
- Giant Axonal Neuropathy
- Glioblastoma Multiforme (Brain Tumor)
- Glioma Grade III and IV
- Glutaric Acidemia Type II
- GM1 Gangliosidosis - Infantile and Juvenile Forms
H
- Hallervorden-Spatz Disease
- Harlequin Ichthyosis - Child
- Head and Neck Cancers - with distant metastasis or inoperable or unresectable
- Heart Transplant Graft Failure
- Heart Transplant Wait List - 1A/1B
- Hematopoietic Stem Cell Transplantation
- Hemophagocytic Lymphohistiocytosis (HLH), Familial Type
- Hepatoblastoma
- Hepatopulmonary Syndrome
- Hepatorenal Syndrome
- Hepatosplenic T-Cell Lymphoma
- Histiocytic Malignancies
- Histiocytosis Syndromes
- Hoyeraal-Hreidarsson Syndrome
- Hunter Syndrome, Type II
- Hurler Syndrome, Type IH
- Hutchinson-Gilford Progeria Syndrome
- Hydranencephaly
- Hypocomplementemic Urticarial Vasculitis
- Hypophosphatasia Perinatal lethal Form
- Hypoplastic Left Heart Syndrome
I
- I Cell disease
- Idiopathic Pulmonary Fibrosis
- Infantile Free Sialic Acid Storage Disease
- Infantile Neuroaxonal Dystrophy (INAD)
- Inflammatory Breast Cancer (IBC)
- Intracranial Hemangiopericytoma
J
- Jervell and Lange-Nielsen Syndrome
- Joubert Syndrome
- Junctional Epidermolysis Bullosa, Lethal Type
- Juvenile Onset Huntington Disease
K
- Kidney Cancer - inoperable or unresectable
- Kleefstra Syndrome
- Krabbe Disease (KD) - Infantile
- Kufs Disease Type A and B
L
- Lafora Disease
- Large Intestine Cancer - with distant metastasis or inoperable, unresectable or recurrent
- Late Infantile Neuronal Ceroid Lipofuscinoses
- Leber Congenital Amaurosis
- Left Ventricular Assist Device (LVAD) Recipient
- Leigh's Disease
- Leiomyosarcoma
- Leptomeningeal Carcinomatosis
- Lesch-Nyhan Syndrome (LNS)
- Lewy Body Dementia
- Liposarcoma - metastatic or recurrent
- Lissencephaly
- Liver Cancer
- LMNA-related Congenital Muscular Dystrophy
- Lowe Syndrome
- Lymphomatoid Granulomatosis Grade III
M
- Malignant Brain Stem Gliomas - Childhood
- Malignant Ectomesenchymoma
- Malignant Gastrointestinal Stromal Tumor
- Malignant Germ Cell Tumor
- Malignant Melanoma with metastases
- Malignant Migrating Partial Seizures of Infancy (MMPSI)
- Malignant Multiple Sclerosis
- Malignant Renal Rhabdoid Tumor
- Mantle Cell Lymphoma (MCL)
- Maple Syrup Urine Disease
- Marshall-Smith Syndrome
- Mastocytosis Type IV
- MECP 2 Duplication Syndrome
- Medulloblastoma with metastasis
- Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS)
- Megalencephaly Capillary Malformation Syndrome (MCAP)
- Menkes Disease - Classic or Infantile Onset Form
- Merkel Cell Carcinoma with metastases
- Merosin Deficient Congenital Muscular Dystrophy
- Metachromatic Leukodystrophy (MLD) - Late Infantile
- Metastatic Endometrial Adenocarcinoma
- Microvillus Inclusion Disease - Child
- Mitral Valve Atresia
- Mixed Dementia
- Mowat-Wilson Syndrome
- Mucosal Malignant Melanoma
- Multicentric Castleman Disease
- Multiple System Atrophy
- Myelodysplastic Syndrome with Excess Blasts
- Myoclonic Epilepsy and Ragged Red Fibers Syndrome
N
- Neonatal Adrenoleukodystrophy
- Neonatal Marfan Syndrome
- Nephrogenic Systemic Fibrosis
- Neuronal Ceroid Lipofuscinoses, Infantile Type
- NFU-1 Mitochondrial Disease
- Nicolaides-Baraitser Syndrome
- Niemann-Pick Disease (NPD) - Type A
- Niemann-Pick Type C
- Nonketotic Hyperglycinemia
- Non-Small Cell Lung Cancer - with metastases to or beyond the hilar nodes or inoperable, unresectable or recurrent
- NUT Carcinoma
O
- Obliterative Bronchiolitis
- Ohtahara Syndrome
- Oligodendroglioma Brain Tumor - Grade III
- OPHN1 Syndrome
- Ornithine Transcarbamylase (OTC) Deficiency
- Orthochromatic Leukodystrophy with Pigmented Glia
- Osteogenesis Imperfecta (OI) - Type II
- Ovarian Cancer - with distant metastases or inoperable or unresectable
P
- PACS1 Syndrome
- Pallister-Killian Syndrome
- Pancreatic Cancer
- Paraneoplastic Cerebellar Degeneration
- Paraneoplastic Pemphigus
- Patau Syndrome
- Pearson Syndrome
- Pelizaeus-Merzbacher Disease - Classic Form
- Pelizaeus-Merzbacher Disease - Connatal Form
- Pericardial Mesothelioma
- Peripheral Nerve Cancer - metastatic or recurrent
- Peritoneal Mesothelioma
- Peritoneal Mucinous Carcinomatosis
- Perry Syndrome
- Pfeiffer Syndrome - Types II and III
- Phelan-McDermid Syndrome
- Pineoblastoma - Childhood
- Pitt Hopkins Syndrome
- Plasmablastic Lymphoma
- Pleural Mesothelioma
- Pompe Disease - Infantile
- Pontocerebellar Hypoplasia
- Posterior Cortical Atrophy
- Primary Cardiac Amyloidosis
- Primary Cardiac Sarcoma
- Primary Central Nervous System Lymphoma
- Primary Effusion Lymphoma
- Primary Intracranial Malignant Melanoma
- Primary Omental Cancer
- Primary Peritoneal Cancer
- Primary Progressive Aphasia
- Progressive Bulbar Palsy
- Progressive Multifocal Leukoencephalopathy
- Progressive Muscular Atrophy
- Progressive Supranuclear Palsy
- Prostate Cancer - Hormone Refractory Disease - or with visceral metastases
- Pulmonary Amyloidosis - AL Type
- Pulmonary Atresia
- Pulmonary Kaposi Sarcoma
R
- Rasmussen Encephalitis
- Refractory Hodgkin Lymphoma
- Renal Amyloidosis - AL Type
- Renal Medullary Carcinoma
- Renpenning Syndrome
- Retinopathy of Prematurity - Stage V
- Rett Syndrome
- Revesz Syndrome
- Rhabdomyosarcoma
- Rhizomelic Chondrodysplasia Punctata
- Richter Syndrome
- Roberts Syndrome
- Rubinstein-Taybi Syndrome
S
- Salivary Tumors
- Sandhoff Disease
- Sanfilippo Syndrome
- Sarcomatoid Carcinoma of the Lung - Stages II-IV
- Sarcomatoid Mesothelioma
- Schindler Disease Type 1
- SCN8A Related Epilepsy with Encephalopathy
- Seckel Syndrome
- Secondary Adenocarcinoma of the Brain
- Severe Combined Immunodeficiency - Childhood
- Single Ventricle
- Sinonasal Cancer
- Sjogren-Larsson Syndrome
- Small Cell Cancer (of the Large Intestine, Ovary, Prostate, or Uterus)
- Small Cell Cancer of the Thymus
- Small Cell Lung Cancer
- Small Intestine Cancer - with distant metastases or inoperable, unresectable or recurrent
- Smith Lemli Opitz Syndrome
- Snijders Blok-Campeau Syndrome
- Soft Tissue Sarcoma - with distant metastases or recurrent
- Spinal Muscular Atrophy (SMA) - Types 0 And 1
- Spinal Nerve Root Cancer - metastatic or recurrent
- Stiff Person Syndrome
- Stomach Cancer - with distant metastases or inoperable, unresectable or recurrent
- Subacute Sclerosing Panencephalitis
- SYNGAP1-related NSID
T
- Tabes Dorsalis
- Tay Sachs Disease
- Taybi-Linder Syndrome
- Tetrasomy 18p
- Thanatophoric Dysplasia, Type 1
- Thymic Carcinoma
- Thyroid Cancer
- Transplant Coronary Artery Vasculopathy
- Tricuspid Atresia
- Trisomy 9
- Turnpenny-Fry Syndrome
U
- Ullrich Congenital Muscular Dystrophy
- Ureter Cancer - with distant metastases or inoperable, unresectable or recurrent
- Usher Syndrome - Type I
- Uveal Melanoma - with Metastases
V
- Vanishing White Matter Disease (CACH) - Infantile and Childhood Onset Forms
W
- Walker Warburg Syndrome
- Warburg Micro Syndrome
- WHO Grade III Meningiomas
- Wolf-Hirschhorn Syndrome
- Wolman Disease
X
- Xeroderma Pigmentosum
- X-Linked Lymphoproliferative Disease
- X-Linked Myotubular Myopathy
Z
- Zellweger Syndrome
- Zhu-Tokita-Takenouchi-Kim Syndrome
Rare Diseases
Many people with rare diseases encounter delays of months or even years when they apply for assistance through SSA. Compassionate allowances allow Social Security to quickly target the most disabled individuals for allowances based on objective medical information that the SSA can obtain quickly.
Often, people with rare diseases are initially denied assistance but later reapply, often with the help of an attorney, and ultimately are approved. The delay and expense of attorney fees can be overwhelming to people who are already coping with serious illness, major medical expenses, and loss of ability to perform normal activities, including work.
Obligation
U.S. Social Security must quickly provide benefits to applicants whose medical conditions are so serious that they meet disability standards. The Compassionate Allowance initiative fast-tracks applications for Social Security disability applicants whose medical conditions are very severe. Many people with rare diseases experience devastating delays when they apply for Social Security assistance because those making the decisions are unfamiliar with their diseases.
The initial list of Compassionate Allowance conditions was developed as a result of information received at public outreach hearings, public comment on an Advance Notice of Proposed Rule-making, comments received from the Social Security and Disability Determination Service communities, and the counsel of medical and scientific experts. The SSA also considered which conditions are most likely to meet its current definition of disability.
The Program is Just a Start
There are 6,000 to 7,000 known rare diseases, many of which could qualify for a compassionate allowance. The National Organization for Rare Disorders (NORD) is committed to working with SSA to bring many rare diseases under this program. The list above will be expanded over time as more fast-track medical conditions are approved. For more information about the program, including a current up to date list of all compassionate allowance conditions, please visit https://www.ssa.gov/compassionateallowances/
Frequently Asked Questions
How many conditions are on the Compassionate Allowances list?
As of August 2026 the list contains 314 conditions, after the Social Security Administration added 14 new conditions that month.
When did the Compassionate Allowances program begin?
The Social Security Administration launched the program in October 2008 with an initial list of 50 conditions, and the list has been expanded many times since then.
Does a Compassionate Allowance increase my monthly disability payment?
No, it only speeds up the medical decision. The payment amount is still based on your earnings record for SSDI or on the federal benefit rate and your countable income for SSI.
Does a Compassionate Allowance waive the five-month SSDI waiting period?
No, SSDI cash benefits still begin after five full months of disability, with ALS as the one exception under a law passed in 2020. SSI has no five-month waiting period.
Will I get Medicare immediately with a Compassionate Allowances approval?
Usually not, because the 24-month Medicare waiting period for SSDI still applies, except for people with ALS. SSI recipients qualify for Medicaid in most states without that wait.
Can children qualify for Compassionate Allowances?
Yes, many listed conditions are childhood disorders, and children can qualify through SSI when the family meets the income and resource limits.
How can I suggest a new condition for the Compassionate Allowances list?
Anyone can submit the name of a condition for consideration through the Compassionate Allowances page on the Social Security website, and the agency reviews submissions against medical and scientific evidence.
What can I do if my Compassionate Allowances claim is denied?
You can appeal by requesting reconsideration, generally within 60 days of the denial notice. Claims are sometimes denied for non-medical reasons such as too few work credits for SSDI or income above SSI limits.
Insights, Analysis, and Developments
Editorial Note: A fast decision is only as good as the paperwork behind it, and the detail that trips up many applicants is in the fine print of the list itself. A large share of entries qualify only in a particular form or at a particular stage - a cancer with distant metastases, an infantile or neonatal type of a metabolic disorder, a specific grade of brain tumor - so a diagnosis that shares a name with a listed condition is not automatically expedited. Anyone applying should have their physician record the diagnosis in the same terms the SSA uses and name the condition plainly on the application. The seven public hearings behind the list, which took testimony on everything from stroke and schizophrenia to autoimmune disease and organ transplants, show that it was built to keep growing, and families living with a rare disease that is not yet included have good reason to check back as new conditions are approved.
Author Credentials: Ian is the founder and Editor-in-Chief of Disabled World, a leading resource for news and information on disability issues. With a global perspective shaped by years of travel and lived experience, Ian is a committed proponent of the Social Model of Disability, a transformative framework developed by disabled activists in the 1970s that emphasizes dismantling societal barriers rather than focusing solely on individual impairments. His work reflects a deep commitment to disability rights, accessibility, and social inclusion. To learn more about Ian's background, expertise, and accomplishments, visit his full biography.