The spinal cord consists of the nerves which connect the brain with the body, and is located in the spinal canal. The spinal canal lies inside the human vertebral column or spine, which is formed by all the vertebrae, the intervertebral discs and ligaments - (More information, including pictures, on the human spinal cord can be found here.)
A spinal cord injury (SCI) is classified as an injury to the spinal cord resulting in a change, either temporary or permanent, in the cord's normal motor, sensory, or autonomic function A spinal cord injury, damage to any part of the spinal cord or nerves at the end of the spinal canal, often causes permanent changes in strength, sensation and other body functions below the site of the injury. The spinal cord does not have to be severed in order for a loss of function to occur. Depending on where the spinal cord and nerve roots are damaged, the symptoms can vary widely, from pain to paralysis to incontinence.
Spinal cord injuries (SCI's) have the potential to cause both loss of sensation and movement below the site of injury in persons who experience them. People may experience a spinal cord injury through trauma to the spine; for example in either a fall, or through a car accident.
People may experience a spinal cord injury which is either incomplete or complete.
In persons who have experienced an incomplete spinal cord injury, they may have some level of both feeling and movement remaining below the site of their injury. Persons with SCI may experience additional issues involving control of urination and bowel movements. People who have spinal cord injuries involving their neck many times require specific devices in order to assist them with breathing.
Terms such as, 'Paraplegia,' 'Quadriplegia,' and, 'Tetraplegia,' are used to describe medical conditions associated with persons who have experienced a spinal cord injury. The terms are used in classifications based on the level and severity of the injury the person has sustained and the affect on their limbs. Persons who live with SCI often find a need to change aspects of both the home and work environments in order to accommodate their disability; however, they continue to live fulfilling and productive lives.
Car accidents are a common cause of SCI - where the spine breaks and exerts pressure on or tears all or a part of the spinal cord; however, there are a number of other causes. Sports injuries, falls, and gunshot wounds are other causes of SCI's. Diseases such as Spina Bifida, Polio, Transverse Myelitis, and Friedreich's Ataxia also cause spinal cord injuries. Damage done to the person's spinal cord may be referred to as a, 'Lesion.' The level of paralysis the person experiences may be referred to as Quadriplegia or Quadriplegia/Tetraplegia if the injury they have sustained is located in their neck area. If the injury they have sustained is in their Lumbar, Thoracic, or Sacral region, the injury may be referred to as Paraplegia.
There is the potential for a person to experience an injury to either their back or neck, resulting in a fracture, without paralysis. If the person's vertebrae have been fractured or dislocated, but their spinal cord has not been damaged, paralysis may not occur. Spinal cord injury is a defining issue in association with SCI.
The terms, 'Complete,' and, 'Incomplete,' in reference to a spinal cord injury are associated with the type of lesion in the person's spine.
Persons with incomplete SCI might have some sensation below the lesion, yet have no movement. There are a number of types of incomplete spinal cord injuries. Every person with an incomplete spinal cord injury is unique in regards to their injury.
Incomplete SCI's are known as:
Persons with SCI face a path of rehabilitation that can be lengthy.
The rehabilitation process often involves a Spinal Cord Injury Treatment Unit, Rehabilitation Center, or Spinal Injury Unit.
Cervical (neck) injuries usually result in full or partial tetraplegia (Quadriplegia). However, depending on the specific location and severity of trauma, limited function may be retained. See the list of C1 to S5 Vertebra functions.
Spinal Cord Injuries (SCI) Include:
Flexion Fracture Pattern
Extension Fracture Pattern
Rotation Fracture Pattern
The American Spinal Injury Association (ASIA) first published an international classification of spinal cord injury in 1982, called the International Standards for Neurological and Functional Classification of Spinal Cord Injury.
A - Indicates a "complete" spinal cord injury where no motor or sensory function is preserved in the sacral segments S4-S5.
B - Indicates an "incomplete" spinal cord injury where sensory but not motor function is preserved below the neurological level and includes the sacral segments S4-S5. This is typically a transient phase and if the person recovers any motor function below the neurological level, that person essentially becomes a motor incomplete, i.e. ASIA C or D.
C - Indicates an "incomplete" spinal cord injury where motor function is preserved below the neurological level, and MORE than half of key muscles below the single neurological level of injury have a muscle grade less than 3 (i.e. M 0 - no contraction, no muscle movement, M 1 - trace of contraction, but no movement, or M 2 - movement with gravity eliminated).
D - Indicates an "incomplete" spinal cord injury where motor function is preserved below the neurological level and at least half of the key muscles ( more than 50 percent of the key muscles) below the neurological level have a muscle grade of 3 or more (I.e. M3, M4 or M5, muscle can movement against gravity (3) or with additional resistance (4 & 5)).
E - If motor and sensation function with ISNCSCI are all graded normal (in all segments) and the patient had neurological deficits from SCI before, then the grade is E.
Note: only patients with SCI receive any AIS grade. The following incomplete syndromes are not part of the International Standards examination : central cord syndrome, Brown -Sequard syndrome, anterior cord syndrome, cauda equina syndrome, conus medullaris syndrome and all neurological deficits caused by lesion of lower motor neurons, i.e. brachial plexus lesions.
There is currently no cure for the paralysis associated with spinal cord injuries. However, there are currently clinical trials being performed involving Olfactory En-sheathing Glial (OEG) cells and Embryonic Stem Cells that show promise.
Today, improved emergency care for people with spinal cord injuries, antibiotics to treat infections, and aggressive rehabilitation can minimize damage to the nervous system and restore function to varying degrees. Advances in research are giving doctors and people living with SCI hope that spinal cord injuries will eventually be repairable. With new surgical techniques and developments in spinal nerve regeneration, cell replacement, neuro-protection, and neuro-rehabilitation, the future for spinal cord injury survivors looks brighter than ever.
In human research, Duke University's Miguel Nicolelis, M.D., revealed groundbreaking details on a brain-machine interface that helps paralyzed patients walk again.
A systematic survey of the scientific literature shows that stem cell therapy can have a statistically significant impact on animal models of spinal cord injury, and points the way for future studies.
1 : Experimental Drug Restores Some Bladder Function After SCI : Ohio State University.
2 : Non-Invasive Spinal Stimulation Enables Paralyzed People to Regain Use of Hands : University of California - Los Angeles.
3 : First Implantation with Swedge Pedicle Screw System - Spinal Resources, Inc : Spinal Resources, Inc..
4 : Exploring Upper Limb Dysfunction After Spinal Cord Injury : Kessler Foundation.
5 : Spinal Cord Injury Recovery Can Be Predicted : University of Zurich.
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