Screen Readers Skip to Content

Department of Defense Gives $5.4 Million to Spinal Cord Injury Research

Published : 2010-08-17 - Updated : 2018-01-26
Author : Christopher & Dana Reeve Foundation

Synopsis* : US DoD $5.4 million grant to support expansion of translational research to find treatments for military men and women with spinal cord injuries.

Main Digest

The United States Department of Defense (DoD) awarded the Christopher & Dana Reeve Foundation a $5.4 million grant to support the expansion of translational research to find treatments for military men and women with spinal cord injuries.

The DoD gave the two-year, peer-reviewed grant to the Foundation's North American Clinical Trials Network (NACTN), an international network of hospitals led by Dr. Robert G. Grossman, chairman of neurosurgery at the Methodist Neurological Institute in Houston.

"Our goal is to bring effective treatments from the lab to the servicemen and women on our front-lines," said Grossman, NACTN's primary investigator. "With the support of DOD and the Reeve Foundation, our network can conduct more high-quality trials that we hope will result in viable therapies for spinal cord injury patients."

NACTN gathers and documents patient medical information in a data registry to better understand the body's natural course of recovery after injury; uses standardized patient assessment protocols and develops new ones; and conducts new trials of therapy for spinal cord injury.

NACTN recently began its first clinical trial this April, a Phase I safety study of Riluzole, a neuroprotective drug that is the only FDA-approved drug used in the treatment of amyotrophic lateral sclerosis, where it prolongs the life spans of patients.

Riluzole acts by blocking the ability of sodium and calcium ions to enter and damage neurons and glia. Laboratory studies have shown it to also be effective in limiting traumatic damage to the spinal cord. If no safety or toxicity issues emerge during the Phase I, a Phase II study of a larger number of patients will be undertaken as an efficacy trial.

NACTN, launched by the Reeve Foundation in 2006, originally had six centers in North America. Since then, the network has expanded to nine clinical sites, a data management center and a pharmacology center.

The new DoD award will enable NACTN to bring several new military hospitals into the network.

"Spinal cord injuries can be devastating and this DoD award affords us the opportunity to test promising interventions in clinical trials and identify effective treatments for this country's war wounded and for spinal cord patients throughout the world," said Susan Howley, the Reeve Foundation's executive vice president for research.

The North American Clinical Trials Network is supported by the Christopher & Dana Reeve Foundation and U.S. Army Medical Research and Material Command under Contract No. W81XWH-10-2-0042.

For information on the Christopher & Dana Reeve Foundation, visit www.christopherreeve.org

 

Source/Reference

Department of Defense Gives $5.4 Million to Spinal Cord Injury Research | Christopher & Dana Reeve Foundation. Disabled World makes no warranties or representations in connection therewith. Content may have been edited for style, clarity or length.

You're reading Disabled World. Be sure to check out our homepage for informative disability news, reviews, sports, stories and how-tos. You can also connect with us on social media such as Twitter and Facebook or learn more about Disabled World on our about us page.

*Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.

Cite Page: Journal: Disabled World. Language: English (U.S.). Author: Christopher & Dana Reeve Foundation. Electronic Publication Date: 2010-08-17 - Revised: 2018-01-26. Title: Department of Defense Gives $5.4 Million to Spinal Cord Injury Research, Source: <a href=https://www.disabled-world.com/disability/types/spinal/dod-sci.php>Department of Defense Gives $5.4 Million to Spinal Cord Injury Research</a>. Retrieved 2021-05-16, from https://www.disabled-world.com/disability/types/spinal/dod-sci.php - Reference: DW#248-4950.