Northwell Health's Feinstein Institute for Medical Research Associate Professor Ona E. Bloom, PhD, along with colleagues at the Marine Biological Laboratory (MBL), published in Scientific Reports that many of the genes that repair an injured spinal cord in a fish called the lamprey are also active in the repair of the peripheral nervous system in mammals.
Lampreys are classified as any jawless fish of the order Petromyzontiformes, placed in the superclass Cyclostomata. There are about 38 known extant species of lampreys. Extensive work on the lamprey started by Carl Rovainen in the 1960s used the lamprey as a model system to work out the fundamental principles of motor control in vertebrates starting in the spinal cord and working toward the brain.
This discovery is significant because it shows the possibility that the same or similar genes may be used to improve spinal cord repair in other animals and perhaps eventually lead to therapeutic developments for humans.
"Scientists have known for many years that the lamprey achieves spontaneous recovery from spinal cord injury, but we have not known the molecular recipe that accompanies and supports this remarkable capacity," said Dr. Bloom, associate professor at the Feinstein Institute and associate professor and director of research at the Zucker School of Medicine at Hofstra/Northwell. "In this study, we have determined all the genes that change during the course of recovery in the lamprey. Now that we have that information, we can use it to test if specific pathways are actually essential to the process."
Lampreys are jawless, eel-like fish that, about 550 million years ago, shared a common ancestor with humans. The observation that a lamprey can fully recover from a severed spinal cord without medication or other treatment is what spurred this study. They can go from paralysis to full swimming behaviors in 10 to 12 weeks.
The researchers analyzed the lampreys' healing process to determine which genes and signaling pathways were activated as compared to a non-injured lamprey. They found the expression of many genes in the spinal cord change over time with recovery and that a number of genes also change in the brain. They also saw that many of the genes associated with the response to spinal cord injury are part of the Wnt signaling pathway, which also plays a role in tissue development and in regeneration in several other animals, like salamanders and zebrafish. These data suggest specific signaling pathways that may be different after spinal cord injury in mammals, like humans, which do not have the same natural regenerative responses.
"This study involved several different labs located in different parts of the country with different types of expertise, but it absolutely could not and would not have been done without the support of the MBL that allows us to work collaboratively in a shared laboratory setting," said Jennifer Morgan, director of the MBL's Eugene Bell Center for Regenerative Biology and Tissue Engineering, one of the authors of the study.
For the paper, Drs. Morgan and Bloom collaborated with other scientists at University of Kentucky and Icahn School of Medicine at Mount Sinai.
The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the Feinstein Institute includes 4,000 researchers and staff who are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine - a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org
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