Epigenetic Clock Distinguishes Between Chronological and Biological Age

Author: Brigham and Women's Hospital
Published: 2017/04/07 - Updated: 2024/04/09
Publication Type: Announcement - Peer-Reviewed: Yes
Contents: Summary - Main - Related Publications

Synopsis: Traditional clocks measure the passage of chronological time and age, an epigenetic clock can also measure biological age. An epigenetic clock is a type of DNA clock based on measuring natural DNA methylation levels to estimate the biological age of a tissue, cell type or organ. Researchers can use this biomarker for aging to find new interventions to extend lifespan, examine conditions that support rejuvenation and study the biology of aging and lifespan control.

Main Digest

Lots of factors can contribute to how fast an organism ages: diet, genetics and environmental interventions can all influence lifespan. But in order to understand how each factor influences aging - and which ones may help slow its progression - researchers need an accurate biomarker, a clock that distinguishes between chronological and biological age. A traditional clock can measure the passage of chronological time and chronological age, but a so-called epigenetic clock can measure biological age.

An epigenetic clock is a type of DNA clock based on measuring natural DNA methylation levels to estimate the biological age of a tissue, cell type or organ. The age of many human tissues and cells is reflected in chemical changes to DNA. Biological aging clocks and biomarkers of aging are expected to find many uses in biological research since age is a fundamental characteristic of most organisms. The finding provides insights for cancer, aging, and stem cell research.

Epigenetic clocks already exist to reflect the pace of aging in humans, but in order to measure and test the effects of interventions in the lab, BWH investigators have developed an age-predicting clock designed for studies in mice. The new clock accurately predicts mouse biological age and the effects of genetic and dietary factors, giving the scientific community a new tool to better understand aging and test new interventions. Their results are published in Cell Metabolism.

To develop their "clock," researchers took blood samples from 141 mice and, from among two million sites, pinpointed 90 sites from across the methylome that can predict biological age. (The methylome refers to all of the sites in the genome where chemical changes known as methylation take place, changing how and when DNA information is read.)

The team then tested the effects of interventions that are known to increase lifespan and delay aging, including calorie restriction and gene knockouts. They also used the clock to measure the biological ages of induced pluripotent stem cells (iPSCs), which resemble younger blood.

The research team hopes that their technique will be useful for researchers who are studying new aging interventions in the lab. Currently, it can take years and hundreds of thousands of dollars to study mice over their lifespans and determine the effectiveness of a single intervention. Although it is no small feat to sequence the entire methylome, the new clock could allow for studies to be carried out much faster and on a larger scale.

"This is a new and much needed tool for studying how changes in diet, environment, genetic manipulations and more can influence health and lifespan," said corresponding author Vadim Gladyshev, PhD, of BWH's Division of Genetics.

"Our hope is that researchers will be able to use this biomarker for aging to find new interventions that can extend lifespan, examine conditions that support rejuvenation and study the biology of aging and lifespan control."

About the Research

Funding for this work was provided by the National Institutes of Health.

Paper cited: Petkovich DA et al. "Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions." Cell Metabolism.

Attribution/Source(s):

This peer reviewed publication pertaining to our Longevity and Life Span section was selected for circulation by the editors of Disabled World due to its likely interest to our disability community readers. Though the content may have been edited for style, clarity, or length, the article "Epigenetic Clock Distinguishes Between Chronological and Biological Age" was originally written by Brigham and Women's Hospital, and submitted for publishing on 2017/04/07 (Edit Update: 2024/04/09). Should you require further information or clarification, Brigham and Women's Hospital can be contacted at the brighamandwomens.org website. Disabled World makes no warranties or representations in connection therewith.

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