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Human Metabolism: Facts and General Information

Disabled World: Revised/Updated: 2019/03/21

Synopsis: Metabolism is a term used to refer to the breakdown of food and its subsequent transformation into energy the persons body needs.

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Defining Metabolism

Metabolism is defined as the set of life-sustaining chemical transformations within the cells of living organisms. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism.

Metabolism is something that consists of both, 'Catabolism,' and, 'Anabolism;' which are the buildup and breakdown of substances. In the field of Biology, Metabolism refers to all of the body's chemical processes, the digestion of food, and the elimination of waste.

Cell Metabolism

Every living cell in a person's body has a metabolism, referred to as, Cell Metabolism. Multicellular organisms such as animals and plants do as well. People have an overall metabolism that differs from the metabolism of individual cells. There are metabolic pathways which form a two-part process; the first part is the one mentioned called, 'Catabolism,' during which the body processes food to use for energy. The other part is called, 'Anabolism,' where the person's body uses food in order to either repair or build cells. The metabolic process ceases only when a person dies.

Catabolism

The term, 'Catabolism,' comes from the Greek word, 'Cata,' which means, 'down.' Catabolism is a process consisting of all of the reactions during which larger molecules are broken down into smaller ones, releasing energy. An example of this process is the digestion of protein which is then broken down into amino acids that a person's body can absorb and use through the metabolic process, storing glycogen in their liver for energy. Chemically, this process is known as an, 'Oxidation Reaction.'

Anabolism

The term, 'Anabolism,' comes from the Greek word, 'Ana,' which means, 'up.' Anabolism is a process consisting of all of the reactions during which the assembly of small molecules are created into larger ones and then stored as energy in newly formed chemical bonds. An example of this is the assembly of amino acids into larger proteins and the subsequent synthesis of fat and glycogen for the person to use as energy. Chemically, this synthetic process is known as a, 'Reduction Reaction.'

Defining Metabolic Rate

The term, 'Metabolic Rate,' refers to the amount of chemical energy a person frees from their body per unit time. Chemical energy is something that is measured in calories, or the amount of energy that will heat one gram of water by one degree Celsius. It is easier to measure calories by kilo-calories, or, 'kcal's'. One kcal is 1,000 calories; something that both food labels and Dietitians refer to as a calorie with a capital, 'C.'. A person's metabolic rate is commonly expressed in terms of kcal's per hour or day. One way to measure someone's metabolic rate is through the use of a, 'Spirometer,' which is a device that measures their rate of oxygen consumption. For every liter of oxygen a person breathes, they use about 4.82 kcal's of energy from glycogen or fat.

A person's metabolic rate is dependent on certain variables such as whether or not they have been fasting, their hormone levels, physical activity, their mental state, and their thyroid hormone in particular. A person's Total Metabolic Rate (TMR) involves their Basic Metabolic Rate (discussed below) in addition to their energy expenditures for other activities. A person's metabolic rate rises due to physical activity, anxiety, eating, pregnancy, fever or other factors. There are factors that can reduce a person's total metabolic rate as well, such as apathy, depression, or prolonged starvation.

Children have a higher TMR than adults. As people near middle-age they gain weight many times, even though they may not change their eating habits. People who pursue diets can become frustrated in part because initial weight lost is from water that is rapidly regained, but also because their TMR declines over time. As their diet process progresses, they burn fewer calories and begin to synthesize more fat, even with a stable intake of calories.

Defining Metabolic States

There are two metabolic states defined as, 'Absorptive,' and, 'Post-absorptive,' which are defined by the time that has elapsed since the person has taken in food and the changes in their body's energy processing. The, 'Absorptive,' state lasts around four hours both during and after a person has eaten a meal. During the absorptive state the person's body absorbs nutrients they have consumed, uses some of them to meet their immediate needs, and converts excess nutrients into energy that is stored. The absorptive state is regulated largely through a hormone called, 'Insulin,' that promotes cellular uptake of glucose, or blood sugar, as well as amino acids, glucose oxidation, the synthesis of fat and glycogen. Due to quick cellular uptake of glucose, a person's blood sugar level falls of because of insulin.

The, 'Post-absorptive,' state usually occurs during the late morning, afternoon hours, and overnight when a person hasn't eaten for four or more hours. During the post-absorptive state the person's stomach and small intestine are empty and their metabolic requirements must be met from energy that has been stored.

Defining Basal Metabolic Rate

A person's Basal Metabolic Rate (BMR) (Basal Metabolic Rate Calculator) is the minimum calorie requirement they need in order to sustain life while resting. A person's BMR may be responsible for burning up to seventy-percent of their total calories they expend, although this figure varies according to various factors. Processes such as pumping blood, respiration, and maintaining body temperature burn calories. A person's BMR is the biggest factor in determining their overall metabolic rate, as well as how many calories they need in order to maintain, lose, or gain weight. A person's BMR is determined by a combination of environmental and genetic factors. These factors include:

Atomic structure of adenosine triphosphate (ATP), a central intermediate in energy metabolism.
Atomic structure of adenosine triphosphate (ATP), a central intermediate in energy metabolism.

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