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Study Finds Lutein May Counter Cognitive Aging

  • Synopsis: Published: 2017-07-25 - Lutein may play a protective role against age-related cognitive decline, suggests a study by University of Illinois kinesiology and community health professor Naiman Khan and postdoctoral researcher Anne Walk. For further information pertaining to this article contact: University of Illinois at Urbana-Champaign at illinois.edu.

Definition: Lutein

Lutein is a xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. Lutein is also present in broccoli, corn, orange pepper, kiwi fruit, grapes, orange juice, zucchini, and squash. Lutein is a natural part of human diet when fruits and vegetables are consumed. According to the NHANES 2013-2014 survey, adults in the United States average 1.7 mg/day of lutein and zeaxanthin combined. In humans, the Observed Safe Level (OSL) for lutein, based on a non-government organization evaluation, is 20 mg/day.

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"Now there's an additional reason to eat nutrient-rich foods such as green leafy vegetables, eggs and avocados, said Naiman Khan."

Spinach and kale are favorites of those looking to stay physically fit, but they also could keep consumers cognitively fit, according to a new study from University of Illinois researchers.

The study, which included 60 adults aged 25 to 45, found that middle-aged participants with higher levels of lutein - a nutrient found in green leafy vegetables such as spinach and kale, as well as avocados and eggs -- had neural responses that were more on par with younger individuals than with their peers. The findings were published in the journal Frontiers in Aging Neuroscience.

"Now there's an additional reason to eat nutrient-rich foods such as green leafy vegetables, eggs and avocados," said Naiman Khan, a professor of kinesiology and community health at Illinois. "We know these foods are related to other health benefits, but these data indicate that there may be cognitive benefits as well."

Most other studies have focused on older adults, after there has already been a period of decline. The Illinois researchers chose to focus on young to middle-aged adults to see whether there was a notable difference between those with higher and lower lutein levels.

"As people get older, they experience typical decline. However, research has shown that this process can start earlier than expected. You can even start to see some differences in the 30s," said Anne Walk, a postdoctoral scholar and first author of the paper. "We want to understand how diet impacts cognition throughout the lifespan. If lutein can protect against decline, we should encourage people to consume lutein-rich foods at a point in their lives when it has maximum benefit."

Lutein is a nutrient that the body can't make on its own, so it must be acquired through diet. Lutein accumulates in brain tissues, but also accumulates in the eye, which allows researchers to measure levels without relying on invasive techniques.

The Illinois researchers measured lutein in the study participants' eyes by having participants look into a scope and respond to a flickering light. Then, using electrodes on the scalp, the researchers measured neural activity in the brain while the participants performed a task that tested attention.

"The neuro-electrical signature of older participants with higher levels of lutein looked much more like their younger counterparts than their peers with less lutein," Walk said. "Lutein appears to have some protective role, since the data suggest that those with more lutein were able to engage more cognitive resources to complete the task."

Next, Khan's group is running intervention trials, aiming to understand how increased dietary consumption of lutein may increase lutein in the eye, and how closely the levels relate to changes in cognitive performance.

"In this study we focused on attention, but we also would like to understand the effects of lutein on learning and memory. There's a lot we are very curious about," Khan said.

This work was supported by the department of kinesiology and community health at the University of Illinois and the Hass Avocado Board.

The paper "The role of retinal carotenoids and age on neuroelectric indices of attentional control among early to middle-aged adults" is available online. DOI: 10.3389/fnagi.2017.00183



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  2. Neighborhood Walkability Can Slow Cognitive Decline - Study shows neighborhoods that motivate walking can stave off cognitive decline in older adults - The University of Kansas
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