Parsley and Celery Help Fight Breast Cancer
Author: University of Missouri
Synopsis and Key Points:
Compound in parsley and other plant products including fruits and nuts can stop certain breast cancer tumor cells from multiplying and growing.
Main DigestParsley, Celery Carry Crucial Component for Fight Against Breast Cancer, MU Researcher Finds - Parsley is usually used as a decorative accent to a scrumptious meal, but don't set it aside just yet.
In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing. The study was published recently in Cancer Prevention Research.
In his study, Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center, exposed rats with a certain type of breast cancer to apigenin, a common compound found in parsley and other plant products. The rats that were exposed to the apigenin developed fewer tumors and experienced significant delays in tumor formation compared to those rats that were not exposed to apigenin. Hyder believes this finding could impact women who are taking certain hormone replacement therapies.
"Six to 10 million women in the United States receive hormone replacement therapy (HRT)," Hyder said. "We know that certain synthetic hormones used in HRT accelerate breast tumor development. In our study, we exposed the rats to one of the chemicals used in the most common HRTs received in the United States - a progestin called medroxyprogesterone acetate (MPA) - which also happens to be the same synthetic hormone that accelerates breast tumor development."
When tumor cells develop in the breast in response to MPA, they encourage new blood vessels to form within tumors. The blood vessels then supply needed nutrients for the tumors to grow and multiply. Hyder found that apigenin blocked new blood vessel formation, thereby delaying, and sometimes stopping, the development of the tumors. Hyder also found that the compound reduced the overall number of tumors. However, while apigenin did delay tumor growth, it did not stop the initial formation of cancer cells within the breast.
Apigenin is most prevalent in parsley and celery, but can also be found in apples, oranges, nuts and other plant products. However, apigenin is not absorbed efficiently into the bloodstream, so scientists are unsure of how much can or should be ingested.
"We don't have specific dosage for humans yet," Hyder said. "However, it appears that keeping a minimal level of apigenin in the bloodstream is important to delay the onset of breast cancer that progresses in response to progestins such as MPA. It's probably a good idea to eat a little parsley and some fruit every day to ensure the minimal amount. However, you can also find this compound in pill supplements in the health food section of many stores. Of course, you should always check with your doctor before making any major changes to your diet or lifestyle."
The next phrase of studies should include human clinical trials to determine the appropriate dosage amount, Hyder said. He believes further study on humans is necessary to address any health and safety issues that might exist.
The research team included Benford Mafuvadze, doctoral student in biomedical sciences, Indira Benakanakere, research scientist Dalton Cardiovascular Research Center; Franklin Lopez, research fellow in the Department of Veterinary Pathobiology; Cynthia Besch-Williford, associate professor of veterinary pathobiology, and Mark Ellersieck, research professor of statistics in the College of Arts and Science.
- 1: Purple Potatoes May Help Kill and Prevent Spread of Colon Cancer : Penn State (2015/08/28)
- 2: Sulforaphane in Vegetables May Improve Autism : Massachusetts General Hospital (2014/10/14)
- 3: Eating Beets Builds a Healthier Brain : Wake Forest University (2010/11/06)
- 4: Beetroot Juice Could Help People Live More Active Lives : University of Exeter (2010/12/17)
- 5: Daily Glass of Beetroot Juice May Lower Blood Pressure : American Heart Association (2013/04/15)
- 6: Live Well By Eating Green Foods : Disabled World (2020/10/01)
- 7: Kidney Patients Medicine Expenses Cut by Eating More Fruit and Vegetables : American Heart Association (2016/09/16)
• Disabled World is strictly a news and information website provided for general informational purpose only and does not constitute medical advice. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. Please report outdated or inaccurate information to us.