Non-Nutritive Sweeteners Can Alter Glycemic Responses and Microbiomes

Definition

Microbiome

The human microbiome is the collection of all microbes, such as bacteria, fungi, viruses, and their genes, that naturally live on our bodies and inside us. Although microbes are so small that they require a microscope to see them, they contribute greatly to human health and wellness. Each body site, for example, the gut, skin, and oral and nasal cavities, has a different community of microbes. Each person has a unique microbiota network originally determined by one's DNA. A person is first exposed to microorganisms as an infant, during delivery in the birth canal, and through the mother's breast milk. Exactly which microorganisms the infant is exposed to depends solely on the species found in the mother. Later in life, environmental exposures and diet can change one's microbiome to either benefit health or place one at greater risk for disease. The human microbiome protects us against pathogens, helps our immune system develop, and enables us to digest food to produce energy.

Main Digest

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance.

Since the late 1800s, non-nutritive sweeteners have promised to deliver all the sweetness of sugar with none of the calories. They have long been believed not to affect the human body. Still, researchers publishing in the journal Cell on August 19, 2022, challenge this notion by finding that these sugar substitutes are not inert and some can alter human consumers' microbiomes in a way that can change their blood sugar levels.

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In 2014, senior author Eran Elinav (@EranElinav), an immunologist and microbiome researcher at the Weizmann Institute of Science and the German National Cancer Center (DKFZ), and his team found that non-nutritive sweeteners affected the microbiomes of mice in ways that could impact their glycemic responses. The team was interested in whether these results would be found in humans.

To address this important question, the research team carefully screened over 1300 individuals for those who strictly avoid non-nutritive sweeteners in their day-to-day lives and identified a cohort of 120 individuals. These participants were broken into six groups: two controls and four who ingested well below the FDA daily allowances of either aspartame, saccharin, stevia, or sucralose.

"In subjects consuming the non-nutritive sweeteners, we could identify very distinct changes in the composition and function of gut microbes and the molecules they secret into the peripheral blood. This seemed to suggest that gut microbes in the human body are rather responsive to each of these sweeteners," says Elinav.

"When we looked at consumers of non-nutritive sweeteners as groups, we found that two of the non-nutritive sweeteners, saccharin, and sucralose, significantly impacted glucose tolerance in healthy adults. Interestingly, changes in the microbes were highly correlated with the alterations in people's glycemic responses."

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To establish causation, the researchers transferred microbial samples from the study subjects to germ-free mice - mice raised in completely sterile conditions and have no microbiome of their own.

"The results were quite striking," says Elinav. "In all of the non-nutritive sweetener groups, but in none of the controls, when we transferred into these sterile mice the microbiome of the top responder individuals collected at a time point in which they were consuming the respective non-nutritive sweeteners, the recipient mice developed glycemic alterations that very significantly mirrored those of the donor individuals. In contrast, the bottom responders' microbiomes were mostly unable to elicit such glycemic responses," he adds.

"These results suggest that the microbiome changes in response to human consumption of non-nutritive sweetener may, at times, induce glycemic changes in consumers in a highly personalized manner."

Elinav says that he expects the effects of the sweeteners will vary from person to person because of the incredibly unique composition of our microbiome.

"We need to raise awareness of the fact that non-nutritive sweeteners are not inert to the human body as we originally believed. With that said, the clinical health implications of the changes they may elicit in humans remain unknown and merit future long-term studies."

"In the meantime, we need to continue searching for solutions to our sweet tooth craving while avoiding sugar, which is most harmful to our metabolic health," says Elinav. "I think drinking only water seems to be the best solution."

Cell, Suez et al. "Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance" https://www.cell.com/cell/fulltext/S0092-8674(22)00919-9

Resources That Provide Relevant Information

• Sugar Substitute Sweeteners
• Are Artificial Sweeteners Safe
• Stevia Sugar Sweetener Substitute
• Diet Soda Increases Belly Fat in Seniors
• Dangers of Aspartame Artificial Sweetener
• Diet Soda and Artificial Sweeteners Bad For Health

Attribution/Source(s):

This peer reviewed article relating to our Fitness and Nutrition section was selected for publishing by the editors of Disabled World due to its likely interest to our disability community readers. Though the content may have been edited for style, clarity, or length, the article "Non-Nutritive Sweeteners Can Alter Glycemic Responses and Microbiomes" was originally written by Cell Press, and published by Disabled-World.com on 2022-08-19 (Updated: 2023-01-04). Should you require further information or clarification, Cell Press can be contacted at cell.com. Disabled World makes no warranties or representations in connection therewith.

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