Screen Readers Skip to Content

Best Tests for Predicting Alzheimer's Disease

Published : 2010-07-01
Author : American Academy of Neurology

Synopsis* : Memory and brain scan tests appear to predict whether a person with cognitive problems might develop Alzheimers disease.

Main Digest

New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's disease.

The research is published in the June 30, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Memory and brain scan tests were performed on 85 people with mild cognitive impairment (MCI) who were part of a larger study called the Alzheimer's Disease Neuroimaging Initiative. The tests included an episodic memory test, in which a participant must correctly recall a list of words. Blood tests were given to measure which form of the APOE gene people had, since one form of the gene is associated with Alzheimer's disease.

MRI brain scans were also used to measure the size of a participant's hippocampus, the part of the brain responsible for learning and memory. Proteins thought to play a role in Alzheimer's disease, called tau or beta-amyloid, were also measured. Finally, a PET brain scan was taken to detect metabolic abnormalities in the brain that might signal Alzheimer's disease.

"Each of these tests have independently shown promise in predicting disease progression, however, prior to the Alzheimer's Disease Neuroimaging Initiative, they had never been compared to one another in the same study before," said study author Susan M. Landau, PhD, with the University of California-Berkeley and a member of the American Academy of Neurology.

Participants were between the ages of 55 and 90 and were followed for an average of 1.9 years. During that time, 28 of the participants developed Alzheimer's disease.

People who showed abnormal results on both PET scans and episodic memory tests were nearly 12 times more likely to develop Alzheimer's disease than those who scored normally on both measures.

"Because people with MCI decline at different rates and some never go on to develop Alzheimer's disease, there is a need for tools that can better predict who might benefit most from treatment," said Landau. "When we compared all of the predictors, these two tests most accurately predicted who developed Alzheimer's."

The study was supported by the National Institutes of Health and the Dana Foundation.

The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as multiple sclerosis, restless legs syndrome, Alzheimer's disease, narcolepsy and stroke.

For more information about the American Academy of Neurology, visit www.aan.com.

You're reading Disabled World. Be sure to check out our homepage for further informative disability news, reviews, disability sports events, exclusive stories and how-tos. You can also find us on Twitter, Facebook, and LinkedIn.

Related Alzheimer's Disease Documents

*Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.

Cite Page: Journal: Disabled World. Language: English (U.S.). Author: American Academy of Neurology. Electronic Publication Date: 2010-07-01. Title: Best Tests for Predicting Alzheimer's Disease, Source: <a href=https://www.disabled-world.com/health/aging/alzheimers/best-test.php>Best Tests for Predicting Alzheimer's Disease</a>. Retrieved 2021-05-07, from https://www.disabled-world.com/health/aging/alzheimers/best-test.php - Reference: DW#187-4498.