Drug Could Improve Alzheimer's Memory Loss
Published : 2009-02-19
Author : Elhuyar Fundazioa
Synopsis* : A drug used in a type of hereditary metabolic disorder improved the memory of laboratory animals with Alzheimers disease.
Main DigestThe research project showed that the drug sodium phenylbutyrate, prescribed until now for patients with alterations in the urea cycle, eases the fusion of proteins responsible for neuron connections, thus increasing the learning capacity of the mice involved. As a result, these discoveries offer new, promising perspectives for the treatment of Alzheimer's Disease and other related dementias.
A drug used in a type of hereditary metabolic disorder improved the memory of laboratory animals with Alzheimer's disease. The results of the project, developed by researchers of the Center for Applied Medical Research (CIMA) of the University of Navarra have been published in the journal Neuropsychopharmacology.
The research project showed that the drug sodium phenylbutyrate, prescribed until now for patients with alterations in the urea cycle, eases the fusion of proteins responsible for neuron connections, thus increasing the learning capacity of the mice involved. As a result, these discoveries offer new, promising perspectives for the treatment of Alzheimer's Disease and other related dementias.
In addition, these findings provide a new alternative to the drugs that are currently available for fighting this devastating disease, explained Dr. Ana Garcia-Osta. Dr. Garcia-Osta is a researcher from the Department of Neurosciences and the principal author of this project.
The research team is currently focused on discovering the acting mechanism in this drug. As the drug is now clinically available and well tolerated, the confirmation of its therapeutic affectively in humans could be applied to Alzheimer's in a shorter period of time than other drugs being studied.
Alzheimer's disease is a neurodegenerative disorder associated with age and characterized by the progressive deterioration of cognitive and intellectual abilities. "Cognitive deficit is associated with a loss of neuron connections. For the memory to develop, it is necessary for a series of cellular and molecular mechanisms to be activated. The interruption of these processes affects the capacity to assimilate and store new memories, explained Dr. Garcia-Osta.
You're reading Disabled World. Be sure to check out our homepage for further informative disability news, reviews, disability sports events, exclusive stories and how-tos. You can also find us on Twitter, Facebook, and LinkedIn.
Related Alzheimer's Disease Documents
- 1 - OCTA Eye Scan May Detect Sign of Early Alzheimer's Disease : Results from two studies show that a new, non-invasive imaging device can see signs of Alzheimer's disease in a matter of seconds.
- 2 - Music Activates Regions of the Brain Spared By Alzheimer's Disease : Researchers at the University of Utah Health looking to the salience network of the brain to develop music based treatments to help alleviate anxiety in patients with dementia.
- 3 - Importance of Family History for Onset of Alzheimer's Disease : Study reveals the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer's disease, the more likely they are to have amyloid plaques, the cause of the cognitive decline.
- 4 - Probiotics Improve Memory in People with Alzheimers Disease : Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: a randomized, double-blind, and controlled trial.
- 5 - Major Study Into Early Signs of Alzheimer's Disease : Deep and Frequent Phenotyping study hopes to dramatically improve success rate of clinical trials for treatments in Alzheimer's disease.
*Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.
Journal: Disabled World. Language: English (U.S.). Author: Elhuyar Fundazioa. Electronic Publication Date: 2009-02-19. Title: Drug Could Improve Alzheimer's Memory Loss, Source: <a href=https://www.disabled-world.com/health/aging/alzheimers/memory-loss-drug.php>Drug Could Improve Alzheimer's Memory Loss</a>. Retrieved 2021-05-07, from https://www.disabled-world.com/health/aging/alzheimers/memory-loss-drug.php - Reference: DW#187-834.