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Ankylosing Spondylitis: Knee, Hip & Spine Pain

  • Synopsis: Published: 2009-11-05 (Revised/Updated 2016-04-01) - Information on Ankylosing Spondylitis a chronic inflammatory arthritis and autoimmune disease affecting spinal joints and causing eventual fusion of the spine. For further information pertaining to this article contact: Ian Langtree at Disabled World.
Ankylosing Spondylitis

Ankylosing Spondylitis, previously known as Bechterew's disease and Marie-Strumpell disease, is an inflammatory disease that can cause some of the vertebrae in your spine to fuse together. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it may be difficult to breathe deeply. The signs and symptoms of ankylosing spondylitis often appear gradually, most commonly between 15 and 45 years of age. Ankylosing spondylitis occurs in 1 in 200 people.

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Quote: "The severity of AS varies greatly from person to person, and not everyone will experience the most serious complications or have spinal fusion."

Ankylosing spondylitis, previously known as Bechterew's disease, Bechterew syndrome, and Marie Strumpell disease, a form of Spondyloarthritis, is a chronic, inflammatory arthritis and autoimmune disease. It mainly affects joints in the spine and the sacroilium in the pelvis, causing eventual fusion of the spine.

The basic pathologic lesion of ankylosing spondylitis occurs at the entheses, which are sites of attachment to bone of ligaments, tendons, and joint capsules. Enthesopathy results from inflammation, with subsequent calcification and ossification at and around the entheses.

In the synovial joints, a proliferative chronic synovitis indistinguishable from rheumatoid arthritis may occur; however, subchondral bone and cartilage are invaded by reactive tissue originating from the bone, which is a feature not encountered in rheumatoid arthritis.

There are more than 100 types of these diseases, including ankylosing spondylitis (AS), rheumatoid arthritis, and lupus.

Early symptoms include back pain and stiffness.

These problems often start in late adolescence or early adulthood.

Over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. Symptoms can worsen or improve or stop altogether.

The disease has no cure, but medicines can relieve the pain, swelling and other symptoms.

Exercise can also help.

Ankylosing spondylitis is two to three times more common in males than in females.

In women, joints away from the spine are more frequently affected than in men.

Ankylosing spondylitis affects all age groups, including children.

The most common age of onset of symptoms is in the second and third decades of life.

The severity of AS varies greatly from person to person, and not everyone will experience the most serious complications or have spinal fusion. Some will experience only intermittent back pain and discomfort, but others will experience severe pain and stiffness over multiple areas of the body for long periods of time.

The type of physician who primarily diagnoses and treats ankylosing spondylitis and related diseases is called a rheumatologist. Rheumatologists treat arthritis, certain autoimmune diseases, musculoskeletal pain disorders and osteoporosis.

A thorough physical exam including x-rays, individual medical history, and a family history of AS, as well as blood work including a possible test for HLA-B27 are factors in making a diagnosis.

Recent studies show that the new biologic medications can potentially slow or halt the disease progression in some people.

The life expectancy of patients with ankylosing spondylitis is the same as that of the general population, except for patients who are severely affected with the disease and in whom complications develop.

In 1982 at the Middlesex Hospital in London, Professor Alan Ebringer and his team began trials to assess the effectiveness of a new Ankylosing spondylitis diet approach to treating AS.

Awareness: Ankylosing Spondylitis Awareness

Blue awareness ribbonThe awareness ribbon color for Ankylosing Spondylitis is blue. The month of April is spondylitis awareness month, and May 7th is Global Ankylosing Spondylitis Day.

Other Awareness ribbon colors

Other awareness dates

Facts: Ankylosing Spondylitis

  • Ankylosing spondylitis occurs in 1 in 200 people.
  • AS symptoms may also present differently in woman.
  • The onset of the disease is typically between 15 and 25 years of age.
  • The disease is most prevalent in Northern European countries, and seen least in people of Afro-Caribbean descent.
  • Many rheumatologists believe the number of women with AS is under-diagnosed, as most women tend to experience milder cases of the disease.
  • The majority of people with AS, including 95 percent of white people with the disease, express the HLA-B27 antigen and high levels of immunoglobulin A (IgA) in the blood.

Related Information:

  1. Ankylosing Spondylitis Diet Information - Jacob Morrow - (2010-01-07)
  2. Announcements to Hasten Arthritis Diagnosis - Spondylitis Association of America - (2010-07-17)
  3. SIMPONI Approved for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis - Centocor Ortho Biotech Inc.; Schering-Plough Corporation - (2009-04-14)

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