Skip to main content
* NOTE: Terms of Service Updated 21 Feb 2018

Viagra May Reduce MS Symptoms

  • Published: 2011-05-19 : Universitat Autonoma de Barcelona.
  • Synopsis: Viagra drastically reduces multiple sclerosis symptoms in animal models with the disease.

Main Document

Universitat Autonoma de Barcelona researchers have discovered that Viagra drastically reduces multiple sclerosis symptoms in animal models with the disease.

The research, published in Acta Neuropathologica, demonstrates that a practically complete recovery occurs in 50% of the animals after eight days of treatment.

Researchers are confident that clinical trials soon will be carried out in patients given that the drug is well tolerated and has been used to treat sexual dysfunction in some multiple sclerosis patients.

Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system and one of the main causes of disability among young adults.

The disease is caused by the presence of multiple focuses of demyelination (loss of myelin sheaths around the axons, affecting the ability of neurons to communicate) and neuro-degeneration in different areas of the central nervous system.

There is currently no cure for the disease, although some drugs have proven effective in fighting symptoms and preventing it from progressing.

A research team from the UAB Institute of Biotechnology and Biomedicine directed by Dr Agustina Garcia, in collaboration with the research team directed by Dr Juan Hidalgo from the UAB Institute of Neurosciences, has studied the effects of a treatment using sildenafil, sold as Viagra®, in an animal model of multiple sclerosis known as experimental autoimmune encephalomyelitis (EAE).

Researchers demonstrated that a daily treatment with sildenafil after disease onset quickly reduced clinical signs, with a practically complete recovery in 50% of the cases after eight days of treatment. Scientists observed how the drug reduced the infiltration of inflammatory cells into the white matter of the spinal cord, thus reducing damage to the nerve cell's axon and facilitating myelin repair.

Sildenafil, together with tadalafil (Cialis®) and vardenafil (Levitra®), form part of a group of vasodilator drugs known as phosphodiesterase type 5 (PDE5) inhibitors, used in the treatment of erectile dysfunction and pulmonary arterial hypertension.

Recent studies in animal models of central nervous system pathologies already pointed to the fact that in addition to vasodilation, these drugs could contain other neuroprotective actions and suggest their usefulness as possible treatments of both acute (cerebrovascular stroke) and chronic (Alzheimer's) neuro-pathologies. In fact, in a research published in 2010 in the Journal of Neurochemistry, the same research group from UAB demonstrated that one of these inhibitors reduced neuroinflammation and neuronal damage in animal models of traumatic brain injury.

Similar Topics

1 : $7M MS Progression Cohort to Research Multiple Sclerosis in Canada : Multiple Sclerosis Society of Canada.
2 : How Can We Predict Whose Multiple Sclerosis Will Worsen? : American Academy of Neurology.
3 : Cladribine Significantly Reduces Brain Atrophy in Patients with Multiple Sclerosis : EMD Inc..
4 : Multiple Sclerosis Onset Age Linked to Geographic Latitude : University of Tasmania.
5 : Stem Cells Show Reversal of Disability in Multiple Sclerosis : Tisch MS Research Center of New York.
From our Multiple Sclerosis section - Full List (48 Items)

Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





1 : Early Childhood Education Needs to be Accessible and Affordable
2 : How the Human Brain Can Tell Our Arms and Legs Apart
3 : Protein Levels in Spinal Fluid Correlate to Posture and Gait Difficulty in Parkinson's Disease
4 : Palliative Care Findings on Caregiver Depression, LGBT Partners, Moral Distress

Citation


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.