Poor Sleep Associated with Greater Rheumatoid Arthritis Disability

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The relationship between sleep quality and disability mediated by pain severity and fatigue.

A study in the Feb. 15th issue of the Journal of Clinical Sleep Medicine found that poor sleep quality correlated with higher levels of depressive symptoms, greater pain severity, increased fatigue, and greater functional disability in patients with Rheumatoid Arthritis (RA). The study suggests that addressing sleep problems via pharmacological or behavioral interventions may have a critical impact on the health and lives of patients with RA.

The study represents a cross-sectional examination of the relationship between sleep quality and functional disability in 162 patients with RA. The sample had an average age of 58.5 years, and 76 percent were female. All patients had been diagnosed with RA for at least two years; on average, patients had RA for 14 years.

Functional Disability

Functional Disability is defined as an irreversible and serious limitation of a person's physical or mental capacity or of their skills that prevents the person from living independently.

Participants completed the following questionnaires:

• Beck Depression Inventory-II
• Health Assessment Questionnaire
• Pittsburgh Sleep Quality Index (PSQI)
• Medical Outcomes Study Short Form - 36

The results provided input on their sleep quality, depression, fatigue, and functional disability and pain severity, respectively. Patients were also provided sociodemographic information and their medical history.

Results show that sleep quality indirectly affects functional disability after controlling for age, gender, and the number of comorbidities. According to the PSQI results, 61 percent of patients were poor sleepers and 33 percent reported having pain that disturbed their sleep three or more times per week.

"The primary finding of our study is that poor sleep quality is associated with greater functional disability among patients with RA and this relationship may be explained by pain severity and fatigue," said lead author Dr. Faith S. Luyster, research assistant professor at the University of Pittsburgh School of Nursing in Pittsburgh, Pa. "These results highlight the importance of addressing sleep complaints among patients with RA. By treating sleep problems either pharmacologically or behaviorally, symptoms and activity limitations associated with RA may be reduced."

The study's finding that poorer sleep quality is associated with greater pain severity is consistent with recent evidence suggesting that sleep disruption may lower pain threshold and enhance pain in RA and otherwise healthy adults.

According to the National Institute of Health, RA is an inflammatory disease affecting about 1.3 million U.S. adults and causes pain, swelling, stiffness, and loss of function in the joints. Disturbed sleep is a major concern among persons with RA.

Physical disability resulting from polyarticular joint disease in patients with RA may limit their ability to carry out daily activities such as dressing, walking, grooming, and writing - tasks that can be further restricted by fatigue, pain severity, and depression.

functional disability may affect depression, pain severity, and fatigue, which in turn may affect sleep quality. The relationships are likely bidirectional to some extent.

"Not sleeping well at night can contribute to greater pain sensitivity and fatigue during the day which in turn can limit a patient's ability to engage in activities of daily living and discretionary activities," Luyster said.

Luyster noted that treating sleep disturbances in RA patients might have beneficial effects beyond improving sleep.

The Study

"Sleep Quality and Functional Disability in Patients with Rheumatoid Arthritis." The study was supported by grants from the National Institute of Health.

The peer-reviewed Journal of Clinical Sleep Medicine is published bimonthly and is the official publication of the American Academy of Sleep Medicine, a professional membership society that is the leader in setting standards and promoting excellence in sleep medicine health care, education, and research.

Attribution/Source(s):

This quality-reviewed article relating to our Rheumatoid Arthritis (RA) section was selected for publishing by the editors of Disabled World due to its likely interest to our disability community readers. Though the content may have been edited for style, clarity, or length, the article "Poor Sleep Associated with Greater Rheumatoid Arthritis Disability" was originally written by American Academy of Sleep Medicine, and published by Disabled-World.com on 2011/02/15 (Updated: 2022/06/04). Should you require further information or clarification, American Academy of Sleep Medicine can be contacted at aasm.org. Disabled World makes no warranties or representations in connection therewith.

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