Osteoporosis Drugs Associated with Decreased Risk of Breast Cancer
- Publish Date: 2010/03/03
- Author: Fred Hutchinson Cancer Research Center
Outline: Common osteoporosis drugs are associated with a decrease in risk of breast cancer.
Main DigestCommon osteoporosis drugs are associated with a decrease in risk of breast cancer...
Women who take some types of bone-building drugs used to prevent and treat osteoporosis may be at lower risk of breast cancer, according to a study by U.S. researchers published today in the British Journal of Cancer.
The study found that women who used bisphosphonate drugs, such as Fosamax, Boniva and Zomita, for more than two years had a nearly 40 percent reduction in risk as compared to those who did not, according to lead author Polly Newcomb, Ph.D., M.P.H., head of the Cancer Prevention Program at Fred Hutchinson Cancer Research Center.
"This large study provides new evidence that the use of bisphosphonates is associated with a potentially important reduction in breast cancer risk," Newcomb said.
The protective effect was observed only among women who were not obese. "Obese women may have elevated estrogen levels, so underlying hormones may influence the ability of bisphosphonates to reduce breast cancer risk," Newcomb said.
The way in which these drugs may prevent breast cancer is not known, but several research observations may be relevant. "These drugs may affect cell function and be important in cell growth and death - specifically the death of tumors or even pre-malignant disease," Newcomb said. Researchers have found that some kinds of bisphosphonates directly cause tumor apoptosis (cellular suicide), inhibit angiogenesis (prevent tumors from establishing a blood supply) and prevent tumor-cell adhesion (the ability of cancer cells to bind to one another).
The study involved nearly 6,000 Wisconsin women, aged 20 to 69. Half had been diagnosed with invasive breast cancer and, for comparison purposes, half had not. The women were interviewed about their bone health - their history of fractures, whether they'd been diagnosed with osteoporosis and their history of bisphosphonate use.
Breast cancer risk factors such as first-degree family history of the disease, age at first birth, postmenopausal hormone use and body mass index were accounted for in the analysis. "Because we were able to account for important co-founders, these findings may reflect real benefits due to the anti-tumor mechanisms of these medications," the authors wrote.
The National Cancer Institute funded the study, which was conducted in collaboration with researchers at the University of Wisconsin Carbone Comprehensive Cancer Center.
About Fred Hutchinson Cancer Research Center
At Fred Hutchinson Cancer Research Center, interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Hutchinson Center researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. www.fhcrc.org
About the British Journal of Cancer (BJC)
The BJC is owned by Cancer Research UK. Its mission is to encourage communication of the very best cancer research from laboratories and clinics in all countries. Broad coverage, its editorial independence and consistent high standards have made BJC one of the world's premier general cancer journals. www.bjc.com
- 1 - Standard of Care for Breast Cancer Survivors with Lymphedema | University of Missouri-Columbia | 2010/02/17
- 2 - Super Micro-surgery Hope for Breast Cancer Patients with Lymphedema | University of Texas M. D. Anderson Cancer Center | 2009/03/23
- 3 - Tips for Breast Cancer Patients During Treatment | Fred Hutchinson Cancer Research Center | 2010/10/27
- 4 - Most Women Do Not Get Recommended Mammograms | American Association for Cancer Research | 2010/12/09
- 5 - Inflammatory Breast Cancer: Facts and Information | Thomas C. Weiss | 2009/01/09
- 6 - 21-Gene Assay - Are Oncologists Jumping the Gun? | National Comprehensive Cancer Network | 2017/04/17
- 7 - More Women Removing Healthy Breast After Cancer Diagnosis | American Cancer Society | 2009/09/28
- 8 - Preventive Mastectomies Pay Off for Some Women | University of Texas Health Science Center at San Antonio | 2010/09/04
Help Spread Disability AwarenessConnect with Us on Social Media