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Acute Myelogenous Leukemia (AML): Symptoms, Treatment, Medications

Published: 2015-09-25 - Updated: 2021-07-27
Author: Thomas C. Weiss | Contact: Disabled World (Disabled-World.com)

Synopsis: General information regarding Acute myelogenous leukemia (AML), a cancer of the bone marrow and blood. In most instances, it is not clear what causes the DNA mutations that lead to leukemia. Radiation, some chemotherapy drugs and certain chemicals are known risk factors for AML. General signs and symptoms of the early stages of acute myelogenous leukemia might mimic those of the flu or other diseases that are common. Signs and symptoms can vary based upon the type of blood cell affected.

Main Digest

Acute myelogenous leukemia (AML) is a cancer of a person's bone marrow and blood. Bone marrow is the spongy tissue inside bones where blood cells are created. The word, 'acute,' in acute myelogenous leukemia concerns the rapid progression of the disease. It is called, 'myelogenous,' leukemia because it affects a group of white blood cells called the, 'myeloid,' cells which usually develop into the different types of mature blood cells such as red blood cells, platelets and white blood cells. Acute myelogenous leukemia is also referred to as:


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AML Symptoms

General signs and symptoms of the early stages of acute myelogenous leukemia might mimic those of the flu or other diseases that are common. Signs and symptoms can vary based upon the type of blood cell affected. Signs and symptoms of AML include the following:

AML Causes

Acute myelogenous leukemia (AML) is caused by damage to the DNA of developing cells in a person's bone marrow. When this occurs, blood cell production becomes something it should not be. The bone marrow produces immature cells that develop into leukemic white blood cells called, 'myeloblasts.' Myeloblasts are unable to function appropriately and they may build up and crowd out cells that are healthy.

In most instances, it is not clear what causes the DNA mutations that lead to leukemia. Radiation, some chemotherapy drugs and certain chemicals are known risk factors for AML.

AML Risk factors

Some different factors exist that might increase a person's risk of acute myelogenous leukemia (AML). Among these risk factors are the ones presented below.

A number of people with AML have no known risk factors. It is important to note this fact, as well as the fact that many people who have risk factors for AML never go on to develop this form of cancer.

AML Tests and Diagnosis

A doctor might recommend a person undergo diagnostic tests if they present with signs or symptoms of acute myelogenous leukemia (AML). The tests may include the following.

Lumbar Puncture:

In some instances, it might be necessary to remove some of the fluid around a person's spinal cord in order to check for leukemia cells. A person's doctor can collect the fluid by inserting a small needle into the person's spinal canal in their lower back.

Bone Marrow Test:

A blood test can suggest leukemia, yet it usually takes a bone marrow test to confirm a diagnosis. During a bone marrow biopsy, a needle is used to obtain a sample of a person's bone marrow. The sample is usually taken from the person's hip bone; the sample is then sent to a laboratory for testing.

Blood Testing:

The majority of people with AML have too many white blood cells, a lack of adequate numbers of platelets, as well as a lack of adequate numbers of red blood cells. The presence of, 'blast cells,' or immature cells usually found in bone marrow, yet not found in blood that is circulating, is another indicator of AML.

If a doctor suspects leukemia, the person might be referred to a doctor who specializes in cancer, or a doctor who specializes in blood and blood-forming tissues.

If a doctor determines that a person has AML, the person might require additional testing to determine the extent of the cancer and to classify it into a more specific AML subtype. A person's AML subtype is based on how their cells appear when they are examined underneath a microscope. Certain laboratory testing may also be used to identify the particular characteristics of the person's cells. A person's AML subtype helps to determine which types of treatments might be best for them. Doctors are studying how different types of cancer treatments affect people with different AML types.

AML Treatments and Medications

Treatment of acute myelogenous leukemia (AML) depends on a number of factors, to include the subtype of the disease, the person's overall health and age, as well as the person's preferences. Generally, treatment falls into two phases which are described below.

Remission Induction Therapy:

The purpose of the first phase of treatment is to kill the leukemia cells in a person's blood and bone marrow. Remission induction therapy; however, does not kill all of the leukemia cells so the person will require additional treatment to prevent the disease from returning.

Consolidation Therapy:

Consolidation therapy is also referred to as, 'maintenance therapy,' post-remission therapy,' or, 'intensification.' In this phase of treatment, the goal is to destroy remaining leukemia cells. It is considered to be crucial in order to decrease the risk of relapse.

During these phases, some different types of therapies are used. These types of therapies include:

Clinical Trials:

Some people with leukemia choose to enroll in clinical trials to attempt experimental types of treatments, or new combinations of known therapies.

Other Medication Therapy:

Arsenic trioxide and all-trans retinoic acid (ATRA) are anti-cancer medications that may be used alone or in combination with chemotherapy for remission induction of a certain subtype of AML called, 'promyelocytic leukemia.' The medications cause leukemia cells with a specific gene mutation to mature and then die, or to cease dividing.

Chemotherapy:

Chemotherapy is the major type of remission induction therapy, although it may also be used for consolidation therapy. Chemotherapy uses chemicals to kill cancer cells in a person's body. People with AML usually remain in the hospital during chemotherapy treatments because the medications destroy many usual blood cells in the process of killing leukemia ones. If the first cycle of chemotherapy does not cause remission, it might be repeated.

Stem Cell Transplant:

A stem cell transplant also called a bone marrow transplant, might be used for consolidation therapy. A stem cell transplant helps to re-establish healthy stem cells by replacing unhealthy bone marrow with leukemia-free stem cells that will regenerate healthy bone marrow. Before a stem cell transplant, the person receives very high doses of radiation therapy or chemotherapy to destroy their leukemia-producing bone marrow. The person then receives infusions of stem cells from a compatible donor called an, 'allogeneic transplant.' A person may also receive their own stem cells if they were previously in remission and had their healthy stem cells removed and stored for a future transplant.

Acute Myelogenous Leukemia (AML) Facts and Statistics

Author Credentials:

Thomas C. Weiss attended college and university courses earning a Masters, Bachelors and two Associate degrees, as well as pursing Disability Studies. As a Nursing Assistant Thomas has assisted people from a variety of racial, religious, gender, class, and age groups by providing care for people with all forms of disabilities from Multiple Sclerosis to Parkinson's; para and quadriplegia to Spina Bifida.

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Cite Page: Journal: Disabled World. Language: English (U.S.). Author: Thomas C. Weiss. Electronic Publication Date: 2015-09-25 - Revised: 2021-07-27. Title: Acute Myelogenous Leukemia (AML): Symptoms, Treatment, Medications, Source: <a href=https://www.disabled-world.com/health/cancer/leukemia/aml.php>Acute Myelogenous Leukemia (AML): Symptoms, Treatment, Medications</a>. Retrieved 2021-08-04, from https://www.disabled-world.com/health/cancer/leukemia/aml.php - Reference: DW#231-11619.