Skip to main content
Accessibility  |  Contact  |  Privacy  |  Terms of Service

Cholesterol Drug May Have Role in Treating Prostate Cancer

  • Published: 2010-09-21 : Author: St. Michael's Hospital
  • Synopsis: Drug commonly prescribed for people with high cholesterol may also be effective in treating prostate cancer.

Main Document

A drug commonly prescribed for people with high cholesterol may also be effective in treating prostate cancer, according to new research by Dr. Xiao-Yan Wen at St. Michael's Hospital.

Rosuvastatin, a statin drug sold as Crestor, suppressed the growth of transplanted human prostate cancer cells in mice.

"Our data provided solid pre-clinical evidence and a strong rationale for clinical trials of statins in the treatment of prostate cancer," said Wen, whose research appears in the September issue of European Urology, the journal of the European Association of Urology.

Prostate cancer is the most common cancer in Canadian men - one in seven men will develop the disease during his lifetime and one in 27 will die from it. Despite improvements in treatments such as surgery, radiation and chemotherapy, many patients still progress to advanced stages.

Recent clinical trials have shown encouraging results regarding the use of angiogenic inhibitors substances that prevent the growth of blood vessels that feed tumors.

Wen and his colleagues in Canada and China screened 2,000 small molecules in zebrafish embryos with 2,000 small molecules. Seven compounds four of them statins slowed or prevented the growth of those blood vessels. They then decided to investigate the cancer-fighting potential of one of those statins, rosuvastatin, and found it suppressed the growth of prostate cancer in mice without apparent side effects.

If human trials confirmed that statin drugs can optimize the benefits of radiation, that would help doctors determine the most effective, less toxic and affordable treatments for their prostate cancer patients.

About St. Michael's Hospital - St. Michael's Hospital provides compassionate care to all who enter its doors. The Hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care and care of the homeless are among the hospital's recognized areas of expertise. Through the Keenan Research Center and the Li Ka Shing Knowledge Institute, research at St. Michael's Hospital is recognized and put into practice around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

Similar Topics

1 : Prostate MRI Reveals More Treatable Cancers and Reduces Overdiagnosis : European Association of Urology.
2 : A More Complete Mediterranean Diet May Protect Against Aggressive Prostate Cancer : Elsevier.
3 : Digital Rectal Exam Vs. PSA Test For Prostate Cancer : Dr. David Samadi Prostate Cancer Center.
4 : First Prostate Cancer Patients Treated with HIFU Technology : HIFU Prostate Services, LLC.
5 : Male Prostate Exam: PSA, DRE and PVR Tests : Dr. David Samadi.
From our Prostate Cancer section - Full List (35 Items)

Submit disability news, coming events, as well as assistive technology product news and reviews.

Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.

Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.

List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.

Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.

1 : Smartphone Addiction is More Addiction to Social Interaction
2 : Actress Eileen Grubba Advocates for Inclusion from Hollywood to the Boardroom
3 : Types of Genetic Mutations Associated with Nephrotic Syndrome Identified
4 : Fighting My Cancer as Much as Possible - Why Many Patients Join Phase 1 Clinical Trials
5 : Social Stigma Can Stand in the Way of Food Insecurity Screening


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.