PSA Level Change Not a Predictor for Prostate Cancer

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Definition

PSA Velocity

Change in Prostate-specific antigen (PSA) over time is formalized in the concepts of PSA velocity and PSA doubling time. PSA velocity is given in ng/ml/year and can be thought of as a prediction: for example, a patient with a current PSA of 2 ng/ml and a PSA velocity of 0.5 ng/ml/year would be expected to have a PSA of 2.5 ng/ml in 12 months. PSA doubling time is the number of months for PSA to increase two-fold.

Main Digest

Researchers at Memorial Sloan-Kettering Cancer Center have found that change in PSA levels over time, known as PSA velocity, is a poor predictor of prostate cancer and may lead to unnecessary biopsies. The new study of more than 5,000 men was published online in the Journal of the National Cancer Institute. Andrew Vickers, Ph.D., Associate Attending Research Methodologist in the Department of Epidemiology and Biostatistics and lead author, said, "We have found no evidence to support the recommendation that men with a high PSA velocity should be biopsied in the absence of other indications. In other words, if a man's PSA has risen rapidly in recent years, there is no cause for concern if his total PSA level is still low and his clinical exam is normal."

Prostate cancer is the most common cancer among American men and the second leading cause of cancer deaths in men, according to the American Cancer Society. While PSA screening is widely used for the early detection of prostate cancer, it is also associated with a high rate of over-diagnosis, which can lead to unnecessary treatment and anxiety.

Currently, early detection guidelines of several organizations (the National Cancer Center Network and the American Urological Association) recommend that men with a rapid rise in PSA or a high PSA velocity have a surgical biopsy for prostate cancer, even if there are no other indicators that cancer may exist. Those indicators could be an elevated baseline PSA or a positive digital rectal exam (DRE).

This study's population came from the Prostate Cancer Prevention Trial. Five thousand five hundred and nineteen men aged 55 years and older with no previous prostate cancer diagnosis, normal DRE, and a baseline PSA of 3.0 ng/mL or less were randomly assigned to finasteride, a drug commonly used to treat enlargement of the prostate gland, more commonly referred to as BPH, or benign prostatic hypertrophy or placebo for seven years. This particular study focused on the men in the placebo group. The men were followed with yearly PSA tests, with biopsy recommended for men with a PSA higher than 4.0 ng/mL. After seven years, all men not diagnosed with prostate cancer were asked to consent to an end-of-study biopsy.

Dr. Vickers and colleagues found no important association between PSA velocity and biopsy outcome after adjusting for risk factors such as age, race, and PSA levels. PSA alone was a much better predictor of biopsy outcome than PSA velocity.

According to Peter T. Scardino, MD, Chair of the Department of Surgery:

"This study should change practice. We have previously published papers determining that PSA naturally varies monthly. We have urged men whose PSA suddenly rises to wait six weeks and repeat the test before agreeing to a needle biopsy. This new study in a large population of men provides even stronger evidence that using changes in PSA as a basis for the recommendation for biopsy leads to many more unnecessary biopsies and does not help to find the more aggressive cancers that we want to find and treat." Dr. Scardino added that "men should be cautious before rushing into a biopsy for minor variations in their PSA level."

The work was funded by the Prostate Cancer Foundation, the Sidney Kimmel Center for Prostate and Urologic Cancers, and a P50-CA92629 SPORE grant from the National Cancer Institute to Dr. Scardino. Additional support was obtained from the National Institutes of Health.

Attribution/Source(s):

This quality-reviewed article relating to our Prostate Cancer section was selected for publishing by the editors of Disabled World due to its likely interest to our disability community readers. Though the content may have been edited for style, clarity, or length, the article "PSA Level Change Not a Predictor for Prostate Cancer" was originally written by Memorial Sloan-Kettering Cancer Center, and published by Disabled-World.com on 2011/02/25 (Updated: 2023/03/16). Should you require further information or clarification, Memorial Sloan-Kettering Cancer Center can be contacted at mskcc.org. Disabled World makes no warranties or representations in connection therewith.

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