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Digital Rectal Exam Vs. PSA Test For Prostate Cancer

  • Published: 2016-09-27 (Revised/Updated 2018-01-19) : Author: Dr. David Samadi Prostate Cancer Center : Contact: ProstateCancer911.com
  • Synopsis: Is the digital rectal exam (DRE) as a screening tool for prostate cancer as good as the prostate specific antigen (PSA) test.

Main Document

"The digital rectal exam has been one of many screening tools in detecting and evaluating a man's risk for prostate cancer, said Dr. David Samadi."

According to a recent study by National Center for Biotechnology Information, PSA testing outperforms DRE in detecting prostate cancer. This analysis confirms those findings indicating that as an independent screening tool, PSA is superior to DRE.

One of the more unpleasant and invasive screening tests men have to endure in checking for prostate cancer is the digital rectal exam (DRE). Now, a recent published literature review is questioning whether this relic from the past still carries the same weight as a screening tool for prostate cancer when there is the more accurate prostate specific antigen (PSA) test available.

"The digital rectal exam has been one of many screening tools in detecting and evaluating a man's risk for prostate cancer," said Dr. David Samadi. "There are always pros and cons to screening tests and the DRE is no different. It can be useful in detecting a few men with prostate cancer but then for some men, the dreaded DRE may be causing them to avoid any testing for prostate cancer altogether."

Researchers from Wake Forest Baptist Medical Center reviewed data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Screening Trial, a nationwide population-based study evaluating cancer screening programs and their impact on cancer mortality. For three years, over 38,000 men from this trial had received DRE exams and PSA tests and then were followed for up to 13 years.

Results showed that a total of 5,064 men had a normal PSA test but an abnormal DRE. Only 2 percent of these men had what is known as clinically relevant prostate cancer meaning that it might needed to be monitored or treated.

The recommendations from this study came to the conclusion that routine DRE screening may be subjecting a large number of men to invasive, potentially uncomfortable examinations for minimal gain. It is now suggested that doctors should share the risks and benefits of DRE with their patients and to let them decide it they want the DRE test or not.

It has been shown in previous studies that PSA does outperform DRE in detecting prostate cancer. This analysis confirms those findings indicating that as an independent screening tool, PSA is superior to DRE.

Ever since 2012 when the United States Preventative Services Task Force recommended against routine PSA testing stating it could lead to over-treatment of slow-growing, harmless tumors, there has been confusion and controversy about what screening methods should be used. The panel did not address DRE which has been the main method of detecting prostate cancer prior to PSA test.

"There will always be the need for DRE testing for other reasons," advised Dr. Samadi.

"Any man with an abnormal PSA and has the decision of whether to have a biopsy or not, should also have a DRE to see if it concurs with the PSA. Also, a DRE is one of the necessary screening tools for detecting rectal or colon cancer. So, it's not completely going away in screening for prostate cancer as the PSA test is seen as more reliable and accurate. The more important thing is for men to be routinely checked for prostate cancer starting at age 40 and to discuss with their doctor a DRE's risks and benefits."

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1 : Prostate MRI Reveals More Treatable Cancers and Reduces Overdiagnosis : European Association of Urology.
2 : A More Complete Mediterranean Diet May Protect Against Aggressive Prostate Cancer : Elsevier.
3 : Digital Rectal Exam Vs. PSA Test For Prostate Cancer : Dr. David Samadi Prostate Cancer Center.
4 : First Prostate Cancer Patients Treated with HIFU Technology : HIFU Prostate Services, LLC.
5 : Male Prostate Exam: PSA, DRE and PVR Tests : Dr. David Samadi.
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