Skip to main content
Accessibility  |  About  |  Contact  |  Privacy  |  Terms

New Mechanism for Controlling Blood Sugar Level Discovered

  • Published: 2010-11-29 (Revised/Updated 2017-01-30) : University of Leicester.
  • Synopsis: New way in which our body controls the levels of sugar in our blood following a meal discovered.

Main Document

Quote: "We found that in order to maintain the correct levels of sugar, a protein present on the cells that release insulin in the pancreas has to be active."

Scientists discover new mechanism for controlling blood sugar level - Advance in understanding of insulin secretion could impact on diabetes control.

Medical scientists at the University of Leicester have identified for the first time a new way in which our body controls the levels of sugar in our blood following a meal.

They have discovered the part played by a particular protein in helping to maintain correct blood sugar levels.

The breakthrough was made in the University of Leicester by a team led by Professor Andrew Tobin, Professor of Cell Biology, who is a Wellcome Trust Senior Research Fellow. The research is published online ahead of print in the prestigious international scientific journal the Proceedings of the National Academy of Sciences.

Professor Tobin said:

"The work, which was done wholly at the University of Leicester, is focused on the mechanisms by which our bodies control the level of sugar in our blood following a meal.

"We found that in order to maintain the correct levels of sugar, a protein present on the cells that release insulin in the pancreas has to be active. This protein, called the M3-muscarinic receptor, is not only active but also needs to undergo a specific change. This change triggers insulin release and the control of blood sugar levels."

Professor Tobin added:

"Without the change in the M3-muscarinic receptor protein sugar levels go up in the same way that we see in diabetes. We are of course testing if the mechanism of controlling sugar levels we have discovered is one of the mechanisms disrupted in diabetes. If this were the case then our studies would have important implications in diabetes."

The paper was authored by:

Kok Choi Kong, Adrian J. Butcher, Phillip McWilliams, David Jones, Sarah E. Munson, Hannah A. Cragg, Alison D. Smart and Andrew B. Tobin at the University of Leicester, Jurgen Wess at the National Institutes of Health, Fadi F. Hamdan at the University of Montreal, Tim Werry at the GlaxoSmithKline, and Elizabeth M. Rosethorne, Steven J. Charlton at Novartis Institutes for Biomedical Research.

The work was funded by the Wellcome Trust

The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust's breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests. www.wellcome.ac.uk

Similar Topics

1 : Prediabetes: The Best Bad News You Can Get : Blue Cross and Blue Shield of Minnesota.
2 : Diabetes Type 1 and 2 On The Rise Among Children and Teens : Centers for Disease Control and Prevention.
3 : Dairy Proteins May Help Control Insulin and Blood Glucose Levels : California Dairy Research Foundation.
4 : Diabetic Foot Care During Winter Months : American College of Foot and Ankle Surgeons.
5 : Diabetes: Dementia & Aging : Thomas C. Weiss.
From our Diabetes section - Full List (65 Items)

Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





1 : Newborns Who Experience Stroke Regain Language Function in Opposite Side of Brain
2 : Cognition and Emotion Play a Role in Predicting Quality of Children's Friendships
3 : Metabolomics - Promising Tool for Advancing in Treatment Personalization of Oncological Patients
4 : Climbing Stairs Lowers Blood Pressure and Strengthens Leg Muscles

Citation


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.