Proof that Irritable Bowel Syndrome (IBS) is not in your Head

Introduction

Proof that a gut-wrenching complaint - irritable bowel syndrome - is not in your head - Identifying a specific cause offers hope for effective treatment.

Main Item

Irritable bowel syndrome makes life miserable for those affected - an estimated ten percent or more of the population.

And what irritates many of them even more is that they often are labeled as hypochondriacs, since physical causes for irritable bowel syndrome have never been identified. Now, biologists at the Technische Universitaet Muenchen (TUM) have shed new light on the matter: They have discovered mini-inflammations in the mucosa of the gut, which upset the sensitive balance of the bowel and are accompanied by sensitization of the enteric nervous system.

Flatulence, constipation and diarrhea, nausea and stomach cramps: Irritable bowel syndrome (IBS) can turn digestion into a nightmare.

Frequent visits to the bathroom are often accompanied by sleep disturbances, headaches, and backaches. In Germany alone, some seven million people are affected by the disorder - and by the fact that their irritable bowel syndrome is often deemed psychosomatic. This is because the organic trigger of the disease has never been discovered, and consequently the various therapeutic interventions are disappointing for both the patients and their doctors. That may soon change, however, because now, for the first time, biologists in Munich have nailed down hidden physical causes of this bowel disorder.

Professor Michael Schemann's research team at the TUM Department for Human Biology has managed to demonstrate that micro-inflammations of the mucosa cause sensitization of the enteric nervous system, thereby causing irritable bowel syndrome. Using ultrafast optical measuring methods, the researchers were able to demonstrate that mediators from mast cells and enterochromaffin cells directly activate the nerve cells in the bowel. This hypersensitivity of the enteric nervous system upsets communication between the gut's mucosa and its nervous system, as project leader Prof. Schemann explains: "The irritated mucosa releases increased amounts of neuro-active substances such as serotonin, histamine and protease. This cocktail produced by the body could be the real cause of the unpleasant IBS complaints."

The TUM researchers in human biology are blazing a trail as they follow this lead.

Their current focus is to what extent nerve sensitization correlates with the severity of symptoms. Working with colleagues from Amsterdam, they have already substantiated the clinical relevance of their results: Irritable bowel symptoms improved after treatment with an antihistamine known for its immune-stabilizing effect in the treatment of allergic reactions such as hay fever. Thanks to funding from the German Research Foundation (DFG), the scientists are now investigating whether the improved symptoms are accompanied by a normalization of nerve activity.

Successful identification of the active components could enable the development of effective drugs to treat irritable bowel syndrome. Even now, though, the TUM team have made life easier for many IBS patients, in that they have shown that the chronic disorder does have physical causes and is not merely "in their heads."

Background

As lead author of the article in "Gastroenterology", research assistant Dr. Sabine Buehner received the 5,000-euro Norgine Gastro Award for outstanding research and discovery in the field of gastroenterology.

The project "The pathophysiology of irritable bowel syndrome: Effect of mucosal biopsy supernatants from patients with irritable bowel syndrome on the enteric nervous system" is funded by the German Research Foundation (DFG).

Original Publications

Buehner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Cremon C, Zeller F, Langer R, Daniel H, Michel K, Schemann M.: Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology. 2009 Oct;137(4):1425-34. (doi:10.1053/j.gastro.2009.07.005)

Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE.: The mast cell stabilizer ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. Published on-line in advance at gut.bmj.com (doi:10.1136/gut.2010.213108)

Attribution/Source(s):

This quality-reviewed publication was selected for publishing by the editors of Disabled World due to its significant relevance to the disability community. Originally authored by Technische Universitaet Muenchen, and published on 2010/08/19 (Edit Update: 2019/02/18), the content may have been edited for style, clarity, or brevity. For further details or clarifications, Technische Universitaet Muenchen can be contacted at . NOTE: Disabled World does not provide any warranties or endorsements related to this article.

▶ Share This Page

Page Information, Citing and Disclaimer

Disabled World is a comprehensive online resource that provides information and news related to disabilities, assistive technologies, and accessibility issues. Founded in 2004 our website covers a wide range of topics, including disability rights, healthcare, education, employment, and independent living, with the goal of supporting the disability community and their families.

Cite This Page (APA): Technische Universitaet Muenchen. (2010, August 19 - Last revised: 2019, February 18). Proof that Irritable Bowel Syndrome (IBS) is not in your Head. Disabled World. Retrieved October 9, 2024 from www.disabled-world.com/health/digestive/ibs-proof.php

Permalink: <a href="https://www.disabled-world.com/health/digestive/ibs-proof.php">Proof that Irritable Bowel Syndrome (IBS) is not in your Head</a>: Proof that a gut-wrenching complaint irritable bowel syndrome IBS is not in your head.

Disabled World provides general information only. Materials presented are never meant to substitute for qualified medical care. Any 3rd party offering or advertising does not constitute an endorsement.