Modest Pregnancy Weight Gain Linked to Higher Autism Risk

Author: University of Utah Health Sciences
Published: 2013/11/06 - Updated: 2025/09/15
Publication Details: Peer-Reviewed, Research, Study, Analysis
Category Topic: Autism Information - Academic Publications

Page Content: Synopsis - Introduction - Main - Insights, Updates

Synopsis: This research, published as a peer-reviewed study in the journal Pediatrics by University of Utah researchers, establishes a modest but consistent association between increased maternal weight gain during pregnancy and autism spectrum disorders in children. The study examined two separate groups totaling over 11,000 children and found that while pregnancy weight gain itself likely doesn't cause autism, it may reflect underlying biological processes shared with ASD development, such as abnormal hormone levels or inflammation. This scholarly work provides valuable insights for families, healthcare providers, and researchers by identifying potential early markers that could help understand autism's gestational origins, while emphasizing that proper prenatal nutrition remains essential and mothers shouldn't alter their diets based solely on these findings - Disabled World (DW).

Introduction

Researchers have uncovered an association between autism spectrum disorders and a small increase in the amount of weight a mother gains during pregnancy. The results of the new study, "Maternal Prenatal Weight Gain and Autism Spectrum Disorders," are published in the November edition of the journal Pediatrics.

Main Content

Previous studies have identified links between women's pre-pregnancy body mass index (BMI) and pregnancy weight gain to an increased risk for the development of autism spectrum disorders (ASD) in children. But in the new study from University of Utah, researchers build on prior research by identifying an association between autism spectrum disorder risk and prenatal weight gain, after accounting for important related factors such as a woman's pre-pregnancy BMI.

"The risk of autism spectrum disorder associated with a modest yet consistent increase in pregnancy weight gain suggests that pregnancy weight gain may serve as an important marker for autism's underlying gestational etiology," said Deborah A. Bilder, M.D., lead author of the study and an assistant professor of psychiatry at the University of Utah.

"These findings suggest that weight gain during pregnancy is not the cause of ASD but rather may reflect an underlying process that it shares with autism spectrum disorders, such as abnormal hormone levels or inflammation."

This small difference in pregnancy weight gain and the association with ASD was found in two separate study groups.

• Researchers carried out the study by comparing the cases of 8-year-olds living in Salt Lake, Davis and Utah counties. A group of 128 children diagnosed with autism spectrum disorders were compared to a control group of 10,920 children of the same age and gender.
• Researchers also examined a second sample group of 288 Utah children diagnosed with autism spectrum disorders and compared their data with that of unaffected siblings.

In both scenarios, pregnancy weight gain patterns obtained from birth certificate records were identified as common factors in mothers who gave birth to children born with autism spectrum disorders. Such a small, but consistent finding suggests that these small changes in pregnancy weight gain and ASD may share the same underlying cause. The mother's BMI at the onset of pregnancy was not linked to ASD in either study group.

ASD data utilized for this study were taken from the Utah Registry of Autism and Developmental Disabilities, a Utah Department of Health (UDOH) registry.

"Utilizing this database to study possible associations that may shed light on the causes of Autism Spectrum Disorder is essential," said Harper Randall, M.D., medical director at the Division of Family Health and Preparedness at UDOH."

"The findings in this study are important because they provide clues to what may increase the risk of having an autism spectrum disorder and provide a specific direction for researchers to pursue as they search for the causes for autism spectrum disorders," said Bilder.

"Doctors have known for a long time that proper nutrition is essential to a healthy pregnancy. Pregnant women should not change their diet based on these results. Rather, this study provides one more piece for the autism puzzle that researchers are exploring."

Autism spectrum disorders are neuro-behavioral disorders manifested by a range of impaired social interactions, abnormal language development, and stereotypic behavior and interests. According to the most recent statistics from the Utah Department of Health, estimates show that 1 in 63 Utah children have an autism spectrum disorder. Another study by the CDC released in 2012 suggests the risk may be even higher, estimating Utah's rate at one in 47. Autism spectrum disorder is no longer considered a rare disorder. It is now recognized in 1 to 2 percent of our population.

"This calls for further investigation of its underlying etiology as a public health concern," said Bilder.

Study Authors

In addition to Bilder, other authors on the study include: Amanda V. Bakian, Ph.D.; Joseph Viskochil, M.Ed.; Erin A.S. Clark, M.D.; Elizabeth L. Botts, M.D.; Ken R. Smith, Ph.D.; Richard Pimentel, MSCS; William M. McMahon, M.D. and Hilary Coon, Ph.D.

Insights, Analysis, and Developments

Attribution/Source(s): This peer reviewed publication was selected for publishing by the editors of Disabled World (DW) due to its relevance to the disability community. Originally authored by University of Utah Health Sciences and published on 2013/11/06, this content may have been edited for style, clarity, or brevity.