Fragile X eIF4E Study Provides Hope for Autism Treatment

Topic: Autism Information
Author: University of Edinburgh
Published: 2014/11/27 - Updated: 2022/07/13
Contents: Summary - Definition - Introduction - Main Item - Related Topics

Synopsis: Researchers identify chemical pathway that goes awry in the brains of Fragile X patients and say the drug could reverse behavioral symptoms. Fragile X Syndrome is the most common genetic cause of autism spectrum disorders. It affects around 1 in 4000 boys and 1 in 6000 girls. Currently, there is no cure. They found that eIF4E regulates the production of an enzyme called MMP-9, which breaks down and re-orders the connections between brain cells called synapses.

Introduction

People affected by a common inherited form of autism could be helped by a drug that is being tested as a treatment for cancer. The scientists have found that a known naturally occurring chemical called cercosporamide can block the pathway and improve sociability in mice with the condition.

Main Item

The team at the University of Edinburgh and McGill University in Canada identified a key molecule - eIF4E - that drives excess protein production in the brains of Fragile X patients. This can cause behavioral symptoms that include learning difficulties. It can also lead to more serious intellectual disabilities, delays in speech and language development and problems with social interactions.

They found that eIF4E regulates the production of an enzyme called MMP-9, which breaks down and re-orders the connections between brain cells called synapses. This disrupts communication between brain cells leading to changes in behavior.

Treatment with cercosporamide blocks the activity of eIF4E, and therefore reduces the amounts of MMP-9, and reverses the behavioral symptoms in mice with a version of Fragile X Syndrome, the team showed.

Cercosporamide is being tested as a treatment for lung cancer and acute myeloid leukemia. The new findings suggest that it could also have a use as a treatment for patients with Fragile X Syndrome.

Fragile X Syndrome is the most common genetic cause of autism spectrum disorders. It affects around 1 in 4000 boys and 1 in 6000 girls. Currently, there is no cure.

The study is published in the journal Cell Reports.

Dr Christos Gkogkas, a Chancellor's Fellow at the University of Edinburgh's Patrick Wild Center for Research into Autism, Fragile X Syndrome and Intellectual Disabilities, said:

"Our findings open the door to targeted treatments for Fragile X Syndrome. By designing treatments that block just this pathway, it is hoped that we can limit the potential side-effects and develop therapies that are more efficient than general treatment approaches."

Professor Peter Kind, Director of the Patrick Wild Center at the University of Edinburgh, said:

"Dr. Gkogkas is an important addition to the Patrick Wild Center. His research provides important insights into the brain processes underlying the symptoms of people with Fragile X Syndrome and other intellectual disabilities. Only with this knowledge can better medicines to treat these conditions be developed."

Professor Nahum Sonenberg, of McGill University, said:

"We found that eIF4E regulates the production of an enzyme called MMP-9, which breaks down and re-orders the connections between brain cells called synapses. Excess MMP-9 disrupts communication between brain cells, leading to changes in behavior."

Related Information

Attribution/Source(s):

This quality-reviewed publication was selected for publishing by the editors of Disabled World due to its significant relevance to the disability community. Originally authored by University of Edinburgh, and published on 2014/11/27 (Edit Update: 2022/07/13), the content may have been edited for style, clarity, or brevity. For further details or clarifications, University of Edinburgh can be contacted at Jen Middleton - jen.middleton@ed.ac.uk. NOTE: Disabled World does not provide any warranties or endorsements related to this article.

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