Quote: "Before the analysis, differences in study design and quality were taken into account to minimize bias."
Research: Acupuncture treatment for pain; Systematic review of randomized clinical trials with acupuncture, placebo acupuncture and no acupuncture groups, BMJ online
The pain relieving effects of acupuncture compared with placebo are small and seem to lack clinical relevance, according to a study published on www.bmj.com today.
Researchers at the Nordic Cochrane Center in Copenhagen analyzed evidence from thirteen acupuncture pain trials involving over 3,000 patients. The trials compared three arms of treatment (real acupuncture, placebo or 'pretend' acupuncture or no acupuncture) for a broad range of common conditions such as knee osteoarthritis, migraine, low back pain and post-operative pain.
Before the analysis, differences in study design and quality were taken into account to minimize bias.
They found a small analgesic effect of real acupuncture compared to placebo acupuncture. This corresponded to a reduction in pain levels of about 4mm on a 100mm pain scoring scale. A 10mm reduction on this scale is classed as 'minimal' or 'little change' so the apparent analgesic effect of acupuncture seems to be below a clinically relevant pain improvement, say the authors.
They found a moderate difference between placebo acupuncture and no acupuncture (10mm on a 100mm pain scoring scale), but the effect of placebo acupuncture varied considerably. Some large trials reported effects of placebo that were of clear clinical relevance (24mm), whereas other large trials found effects that seemed clinically irrelevant (5mm).
The authors could not explain this variation, but they did not find an association between the type of placebo acupuncture and its effect.
Our findings correspond with several Cochrane reviews on acupuncture for various types of pain, which all concluded that there was no clear evidence of an analgesic effect of acupuncture, say the authors.
Our findings also question both the traditional foundation of acupuncture and the prevailing theory that acupuncture has important effect on pain in general.
They suggest that future trials focus on reducing bias and trying to separate the physiological effect of using a needle and the psychological impact of the treatment ritual.
In an accompanying editorial, Dr Adrian White and Dr Mike Cummings of the British Medical Acupuncture Society suggest that although the overall effect of acupuncture in relation to usual care is not large, it may be clinically relevant for musculoskeletal conditions, particularly in view of the limited treatment options, and acupuncture's safety record and patient preference.
They believe that future research should focus on comparing acupuncture with best existing treatments for different conditions.
Acupuncture seems, in part at least, to use neurological pathways in common with placebo analgesia and the study of these may offer important insights into improving care, they conclude.
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