Safety of Probiotics Reviewed by Experts

Topic: Probiotics and Prebiotics
Author: International Scientific Association for Probiotics and Prebiotics - Contact: isappscience.org
Published: 2023/04/14
Contents: Summary - Definition - Introduction - Main Item - Related Topics

Synopsis: A scientific group confirms that probiotics are generally safe and provide comprehensive guidance on potential probiotic risks. A new review by experts in probiotic science considers if emerging evidence raises any new safety concerns for probiotics. The experts aimed to provide both scientists and healthcare professionals with guidance on how to assess probiotic safety-including for strains without a history of safe use.

Defining Probiotics and Prebiotics

Probiotics and Prebiotics

Probiotics:

Probiotics are tiny living microorganisms, including bacteria and yeast, found in some foods or supplements that provide health benefits. The World Health Organization (WHO) defines probiotics as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." Probiotics are part of a bigger picture concerning bacteria and your body - namely your microbiome. Live probiotic cultures are part of fermented dairy products, other fermented foods, and probiotic-fortified foods and can be obtained from foods such as yogurt and sauerkraut. Lactobacillus is one of the most common probiotics.

Prebiotics:

Prebiotics are a form of dietary fiber that feed friendly bacteria in your digestive system. Prebiotics are special plant fibers that help healthy bacteria grow in your gut. This makes your digestive system work better by allowing your gut bacteria to produce nutrients for your colon cells, which leads to a healthier digestive system. Prebiotics come from types of carbohydrates (sugars, starches, and fibers found in fruits, grains, vegetables, and milk products) but mainly fiber that humans can't digest. The beneficial bacteria in your digestive system eat this fiber. Prebiotics can be obtained from foods such as onions, garlic, soybeans, whole grains, bananas, greens, and artichokes. In addition, probiotics and prebiotics are added to some foods and are also available as dietary supplements.

Introduction

"Emerging issues in probiotic safety: 2023 perspectives" - Gut Microbes.

Scientific evidence assessing the benefits and risks of probiotics continues to accumulate. With new types of probiotics being introduced on the market and healthcare professionals recommending probiotic use in populations other than generally healthy individuals, continual attention to probiotic safety is warranted.

Main Item

A new review* by experts in probiotic science considers if emerging evidence raises any new safety concerns for probiotics. The review provides a comprehensive list of potential probiotic risks, along with recommendations for assessing whether a given probiotic product is safe. The 17 experts, specialists in microbiology, food science, pediatrics, family medicine and related fields, were convened by the International Scientific Association for Probiotics and Prebiotics (ISAPP). The experts aimed to provide both scientists and healthcare professionals with guidance on how to assess probiotic safety-including for strains without a history of safe use.

Corresponding author Dr. Mary Ellen Sanders, PhD, says:

"While traditional probiotics have a good safety record based on many published clinical trials and history of safe use, not all uses of probiotics are equally safe. This paper emphasizes that probiotics administered to at-risk populations must be fit-for-purpose, which in some cases requires additional safety scrutiny."

The experts acknowledged in this paper the increased reporting of microbiome data in probiotic studies. A few isolated studies have suggested that certain probiotic preparations may adversely affect the microbiome, through reduction of diversity or hindering microbiome recovery after antibiotics. This review concludes that such observations, while interesting mechanistically, lack evidence of clinical or health-related impact, and therefore do not pose actionable safety concerns.

The authors provide recommendations for addressing possible probiotic risks, including issues specific to probiotic strains, quality of probiotic manufacture, and risks inherent to practices of probiotic administration. Potential concerns about probiotic safety were considered from both acute and long-term safety perspectives.

First author Prof. Daniel Merenstein, MD, says:

"Probiotics have been proven to have efficacy in several indications. But as is the case with every intervention, there is always the potential for harm. Human trials need to do a better job of assessing harm and we hope this article provides current perspective on how to properly do this. Existing literature demonstrates that probiotics have a very good acute safety record. However, like almost all interventions we use in medicine, the long term impact is understudied."

The authors say for novel probiotics, analyzing the entire genetic makeup of a microorganism is a cornerstone for assessing its safety. Not only does this allow precise strain identification, but it can also illuminate any genes of concern, which may confer toxigenicity, pathogenicity or antibiotic resistance.

The review provides important guidance for healthcare professionals who currently recommend probiotics to their patients, and serves as a call for continued attention to probiotic safety in future scientific studies.

About ISAPP

ISAPP is a nonprofit organization founded in 2002 to advance the science of probiotics and prebiotics, and more recently synbiotics, postbiotics, and fermented foods. ISAPP communicates scientifically accurate information to healthcare providers, scientists, consumers, and regulatory bodies through its many resources.

* https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2185034

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