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First Aid for Lyme Disease After a Tick Bite

  • Synopsis: Published: 2011-12-19 - Information on applying a gel to the bite area after the tick has been removed to prevent Lyme borreliosis. For further information pertaining to this article contact: Fraunhofer-Gesellschaft.
Lyme Disease
Lyme disease or Lyme borreliosis - An emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most European cases. The disease is named after the town of Lyme, Connecticut, USA, where a number of cases were identified in 1975. Although Allen Steere realized that Lyme disease was a tick-borne disease in 1978, the cause of the disease remained a mystery until 1981, when B. burgdorferi was identified by Willy Burgdorfer.

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They come out in the spring, and each year they spread further - the ticks. Thirty percent of them transmit borrelia pathogens, the causative agent of Lyme borreliosis that can damage joints and organs. The disease often goes undetected. In the future, a new type of gel is intended to prevent an infection - if applied after a tick bite.

For years, Mrs. S. suffered from joint pain and headaches. After an odyssey through doctors' waiting rooms, one doctor diagnosed Lyme borreliosis - an infectious disease transmitted by ticks. With its bite, the parasite introduced bacteria that then spread throughout the entire body.

Mrs. S. is not alone - very often, the disease is recognized too late or not at all, or is not properly treated. Doctors are provided with no clues if the characteristic redness around the bite area is missing. Left untreated, Lyme borreliosis can cause symptoms that resemble rheumatism, damage joints, muscles and nerves and affect the organs.

If found in time, it can be successfully treated. If patients exhibit the disease-specific rash known as erythema migrans, doctors will prescribe antibiotics for several weeks. However, if, as in the case of Mrs. S., the disease has progressed far and is chronic, it is very difficult to treat. Currently, there is no prophylactic treatment and no vaccine against the infection. In the future, a new type of gel is supposed to nip the infection in the bud: the patient applies it locally immediately after the tick's bite. Researchers of the Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig developed the medication in close cooperation with the Swiss company Ixodes AG and the Institute for Infectious Diseases and Zoonoses of the Ludwig-Maximilian University in Munich (Institut fur Infektionsmedizin und Zoonosen der LMU Munchen). Ixodes AG is responsible for developing the formula, while IZI and LMU are carrying out the pre-clinical studies and the serological examinations.

"If the gel is applied immediately to the bite after the tick has been removed and one does not wait for any potential symptoms to show, Lyme borreliosis could be prevented. This is because during the first few days, the bacteria stay right around the spot where the tick bite occurred and spread out only after that. The active ingredient of the gel is azithromycin, which is highly effective against borrelia bacteria and kills them locally in the skin," says Dr. Jens Knauer, project manager at IZI. Unlike other antibiotics, there is no known resistance of borrelia strains against azithromycin. Another advantage of the active ingredient: it has few side effects and as a result does not stress the body. It also distinguishes itself by its good depot action of up to five days in the tissue. The treatment is successful only if the medication is applied within the first few days after the tick's bite. "This gel, however, cannot be used to treat an established infection; it is suitable only for prophylaxis," emphasizes Dr. Knauer.

The pre-clinical studies have already been completed successfully; in mice, the gel was effective even five days after a tick's bite. The application has been patented. Starting this past summer, in a clinical phase III study (www.zeckenstudie.com), the researchers are testing the medication on persons with proven tick bites. "Should the results of the pre-clinical studies be confirmed on humans, the gel will help to significantly lower the number of new infections," the expert adds. Annually, up to 60,000 are stricken with Lyme borreliosis in Germany alone, according to estimates by the Robert Koch Institute, with an upward trend - since, due to climate change, ticks are expanding their range ever further. "As soon as the gel can be purchased at the pharmacy, persons who are particularly endangered, such as forest rangers, hunters, joggers or soccer players, should always carry it with them," Knauer recommends.

Related Information:

  1. How to Remove a Tick to Prevent Lyme Disease - If a tick is removed within 24 hours, the chances of it transmitting Lyme disease or other infections are much less because the risk of contracting infection increases between 24 to 72 hours after the tick attaches to the skin.
  2. Lyme Disease Cookbook and Recipes - Book includes 151 recipes plus practical tips designed to help anyone feel better through healthier eating. It is especially helpful for people with Lyme disease and other ailments, as it supports the anti-inflammation diet.
  3. Lyme Disease Research - More Aggressive Treatments - Standard treatment following a tick bite is two weeks of antibiotics. However, longer-term, more aggressive treatment with antibiotics can help prevent Lyme disease in some people.




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