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Extending Shelf Life of Vaccines

Published: 2022-08-07 - Updated: 2023-01-04
Author: ETH Zurich | Contact: ethz.ch/en.html
Peer-Reviewed Publication: Yes | DOI: https://www.science.org/doi/10.1126/sciadv.abo0502
Additional References: Immunization and Vaccines Publications

Synopsis: Nearly half of all vaccines go to waste due to obstacles involved in transporting them, as most vaccines require strict temperature regulation from the manufacturing line to the injection site. The new gel material is based on a biocompatible, synthetic polymer known as "PEG" that serves as a protective, "cloaking device" for very large - yet invisible to the naked eye - complex molecules such as proteins found in vaccines, antibodies, or gene therapies. The packaging works like a molecular Tupperware, encapsulating and separating the proteins. It enables the proteins to withstand a higher range of temperature fluctuations.

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Definition

Vaccine

A vaccine is a substance used to stimulate the production of antibodies and provide immunity against one or several diseases, prepared from the causative agent of a disease, its products, or a synthetic substitute, treated to act as an antigen without inducing the disease. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and further recognize and destroy any microorganisms associated with that agent that it may encounter in the future. Vaccines can be either prophylactic (preventive) or therapeutic (to fight a disease that has already occurred). According to the U.S. Centers for Disease Control and Prevention (CDC), vaccines have reduced preventable infectious diseases to an all-time low. Few people experience the devastating effects of measles, pertussis, and other illnesses.

Main Digest

Thermal Stabilization of Diverse Biologics Using Reversible Hydrogels

Nearly half of all vaccines go to waste. This is due to the logistical obstacles involved in transporting them to diverse regions of the world. Most vaccines require strict temperature regulation from the manufacturing line to injection into a human arm. Maintaining a constant temperature along the cold (supply) chain is challenging in the best circumstances. In Sub-Saharan Africa and other developing regions, for example, limited transport infrastructure and unreliable electricity compound the already immense challenges of delivering viable vaccines.

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Rising to the challenge, scientists from ETH Zurich's Macromolecular Engineering and Organic Chemistry Labs and entrepreneurs from Colorado-based Nanoly Bioscience worked together to develop a safe, versatile platform to increase the thermal stability of vaccines. Their aim? To vastly improve the distribution of viable vaccines and reduce the economic costs of the cold chain.

Like "Tupperware" for proteins, "Think of it like an egg," explains Bruno Marco-Dufort, a doctoral researcher in Professor Mark Tibbitt's Macromolecular Engineering lab.

"At room temperature or in the refrigerator, the egg maintains its viscous-like protein structure, but once it hits boiling water or the frying pan, its structure changes. Permanently."

It is similar to the proteins in a vaccine - once exposed to certain temperatures, they clump together. Cooling them down again will not reverse their denaturation - you cannot 'un-cook' the egg.

So, rather than altering mother nature, Marco-Dufort and the research team developed a new type of hydrogel, the details of which were just published in the journal Science Advances. The gel is based on a biocompatible, synthetic polymer known as "PEG" that serves as a protective, "cloaking device" for very large - yet invisible to the naked eye - complex molecules such as the proteins found in vaccines, antibodies, or gene therapies.

Artistic rendering of the gels encapsulating a viral vaccine - Image Credit and Copyright Holder: ETH Zurich / Jonathan Zawada.
Artistic rendering of the gels encapsulating a viral vaccine - Image Credit and Copyright Holder: ETH Zurich / Jonathan Zawada.

The packaging works like a molecular Tupperware, encapsulating the proteins and keeping them separated. It enables the proteins to withstand a higher range of temperature fluctuations. Instead of the traditional +2 to +8 °C (35 to 45 °F) range for the cold chain, encapsulation allows for a range of 25 to 65 °C (75 to 150 °F). Most importantly, the encapsulated cargo is released by adding a sugar solution, enabling easy on-demand recovery of the vaccines at their point of use.

Usage in cancer research In addition to a higher rate of vaccine viability, the real game changer of this new biomedical hydrogel technology is the potential economic effect it could have on reducing costs and health risks associated with the cold chain.

"In 2020, the overall market for cold chain services (from manufacturing to distribution) was $17.2 billion and forecasted to rise," the researchers reported.

Rising costs potentially pose dire consequences for public health and trust if vaccines arrive via a compromised cold chain.

"Most vaccines are sensitive to hot and cold. This creates a large barrier for global immunization campaigns because vaccine distribution and administrative costs often exceed the costs of production," explains Marco-Dufort.

While more investment will be needed to shore up the cold chain, encapsulation offers a cost-saving solution to produce more vaccines and thus, save more lives.

There is still a long way to go regarding further research, safety studies, and clinical trials before the hydrogels can be implemented for vaccine distribution. Their more immediate use is for transporting heat-sensitive enzymes used in cancer research, for example, or protein molecules for research in lab settings.

One step towards solving a global issue While new biotechnologies and cost savings are a step in the right direction, there are still tremendous logistical, political, and socio-economic challenges in resolving the global issues surrounding equitable vaccine distribution and vaccine hesitancy.

Marco-Dufort's motivation is undeterred. His childhood experience living in the Democratic Republic of the Congo instilled a deep appreciation for the need for vaccines against infectious diseases, not just for Covid-19 but also for Polio, Meningitis, and Ebola. He, more than most, is aware of the tremendous challenges people living in Sub-Saharan Africa face regarding access to vaccines where infectious diseases are still prevalent.

Mark Tibbitt, Bruno Marco-Dufort, and the team's work represent a substantive advancement in vaccine excipient development. Their work also offers a glimmer of hope for a positive societal impact. Even a small relief of the economic factors associated with the distribution of vaccines, medicines, and biomedical research could result in larger impacts down the road.

Reference Source(s):

Extending Shelf Life of Vaccines | ETH Zurich (ethz.ch/en.html). Disabled World makes no warranties or representations in connection therewith. Content may have been edited for style, clarity or length.

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Cite This Page (APA): ETH Zurich. (2022, August 7). Extending Shelf Life of Vaccines. Disabled World. Retrieved January 30, 2023 from www.disabled-world.com/medical/immunization/hydrogels.php

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