Nanotechnology Helps Deliver Drugs to Intestinal Target
Author: Inderscience Publishers
Synopsis and Key Points:
Nanoparticle drug delivery could be beneficial for patients suffering from inflammatory bowel diseases including Crohns Disease ulcerative colitis and irritable bowel syndrome.
Main DigestNanoparticles could help smuggle drugs into the gut, according to a study published this month in the International Journal of Nanotechnology.
There are several drugs that would have more beneficial therapeutic effects if they could be targeted at absorption by the lower intestine. However, in order to target the colon for treating colon cancer for instance, medication delivered by mouth must surmount several barriers including stomach acidity, binding to mucus layers, rapid clearance from the gut, and premature uptake by cells higher up the gastrointestinal tract. Being able to deliver a drug by mouth has several benefits over injection or suppository: ease of dosing, for instance, and better patient compliance.
Various methods have been tried, including coating drug molecules with a polymer shell. However, Kevin P. O'Donnell and Robert O. Williams III of the Division of Pharmaceutics, at The University of Texas at Austin, have reviewed the various techniques on offer and suggest that encapsulating a drug molecule within nanoparticles offers the best option for controlling drug delivery and targeting the colon.
The Texas team has reviewed the state of the art in nanotechnology for delivery of therapeutic agents to the colon. They explain that advances in particle engineering techniques have recently made it possible to made drug products on the nanoscale. Techniques such as spray drying, anti-solvent methods, dialysis methods, emulsion methods and cryogenic methods are all now available for drug formulation. Converting a drug powder into nanoparticles can often render a compound that is poorly soluble in water soluble or increase bioavailability simply through an increase in the surface area to volume ratio. Smaller particles mean a bigger surface area to interact with absorbing surfaces in the gastrointestinal tract. Indeed, fatty but solid nanoparticles of the compound quercetin (a health supplement) are absorbed almost 6 times more effectively by the gut in nanoparticle form than the common drug suspension formulation.
The researchers explain that nanoparticle drug delivery could be particularly beneficial for patients suffering from inflammatory bowel diseases including Crohn's Disease, ulcerative colitis and irritable bowel syndrome, all which often require long-term treatment. However, they also add that because there are no digestive enzymes in the colon and its neutral pH it is a prime target for the delivery of therapeutic proteins, peptides, viral vectors, and nucleotides for a wide range of disease not simply those associated with the colon.
"Nano-particulate systems for oral drug delivery to the colon" in International Journal of Nanotechnology, 2010, 8, 1/2, 4-20
- 1 - Magnetic Nanoparticles May Stop Blood Clot Strokes : Houston Methodist (2015/02/23)
- 2 - Nanoparticles Injected After Spinal Cord Injury Limit Damage, Inflammation and Scarring : Northwestern University (2017/09/05)
- 3 - Preventing Cancer Metastases : Spaser Used to Destroy Tumor Cells : Georgia State University (2017/08/21)
- 4 - New Artificial Retinas Use 2D Materials : American Chemical Society (ACS) (2018/08/25)
- 5 - Dangers of Nanoparticles in the Environment Cause for Concern : University of Southern Denmark (2018/08/22)
- 6 - Nanoparticle Drug Delivery Targets Kidney Diseases : University of Southern California (2018/08/21)
- 7 - Nanoparticle Nanocages: A Golden Bullet for Cancer? : Washington University in St. Louis (2010/03/13)
• Disabled World is strictly a news and information website provided for general informational purpose only and does not constitute medical advice. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World.