Skip to main content
About | Contact | Privacy | Terms

Bariatric Surgery Linked to Major Health Benefits

  • Published: 2014-04-23 (Revised/Updated 2016-04-06) : University of Gothenburg.
  • Synopsis: Bariatric surgery has positive effects not only on weight loss but also on diabetes and heart disease
Bariatric

The branch of medicine that deals with the causes, prevention, and treatment of obesity.

Main Document

Quote: "This is a major breakthrough in understanding how bariatric surgery affects metabolism and in the development of new treatment strategies"

Researchers at the Sahlgrenska Academy and University of Cincinnati have shown that the health benefits are not caused by a reduction in the stomach size but by increased levels of bile acids in the blood. These findings, reported in Nature, indicate that bile acids could be a new target for treating obesity and diabetes.

Previous research from the Sahlgrenska Academy has demonstrated that obesity surgery is the only effective treatment for obesity and obesity-related diabetes.

However, the mechanisms that cause the positive effects have been unclear.

Positive effects caused by bile acids

Professor Fredrik Backhed, in collaboration with Randy Seeley and coworkers from the University of Cincinnati in the US, has shown that the positive effects of bariatric surgery are likely caused by the surgery-induced increase in bile acids. The study, which is published online in the leading science journal Nature, focuses on a specific receptor called FXR, which is involved in bile acid signaling.

"Our study shows that signaling through FXR is essential for the beneficial effects of the surgery to be achieved. This is a major breakthrough in understanding how bariatric surgery affects metabolism and in the development of new treatment strategies", says Fredrik Backhed.

Important future complement

The prevalence of obesity is increasing worldwide and it is not realistic to operate on all obese subjects. Furthermore, bariatric surgery is associated with a risk of complications. Treatment strategies based on the FXR receptor could therefore be an important future therapeutic approach.

Improves glucose metabolism

In this study, mice with or without the FXR gene underwent an operation termed vertical sleeve gastrectomy (VSG) in which approximately 80 percent of the stomach was removed. The surgical procedure is the same as that performed in humans.

The researchers observed that the operation promoted weight loss and improved glucose metabolism in mice with FXR while the operation had no effect in mice that lacked FXR.

Alters intestinal bacterial flora

This study also showed that VSG resulted in changes in the gut microbiota, a potentially important finding given that Fredrik Backhed's research group has previously demonstrated that the intestinal bacterial flora is altered in obesity and diabetes.

These additional findings suggest that an altered gut flora together with signaling through FXR may contribute to improved metabolism. This means that future treatments based on the intestinal flora could help in the treatment of diabetes.

The article FXR is a molecular target for the effects of vertical sleeve gastrectomy was published online in Nature on 26 March - www.nature.com/nature/index.html

Related Information:

  1. Call for Universal Coverage for Bariatric Surgery and Obesity Treatments - American Osteopathic Association - (Jul 22, 2012)
    https://www.disabled-world.com/medical/bariatric-surgeries.php
  2. What are Bariatric Aids, Products or Equipment - Disabled World - (Jul 10, 2012)
    https://www.disabled-world.com/assistivedevices/medical/bariatrics.php
  3. Bariatric Surgery and Bone Loss - Research Australia - (Nov 12, 2012)
    https://www.disabled-world.com/health/orthopedics/bariatric-bones.php


Information from our Medical Research: News & Information section - (Full List).

Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





  1. Stuttering: Stop Signals in the Brain Prevent Fluent Speech
  2. New Peer-reviewed Journal 'Autism in Adulthood' Launching in 2019
  3. People Want to Live Longer - But Only If in Good Health
  4. Canada's Aging Population Signals Need for More Inclusive, Accessible Transportation System

Citation



Disclaimer: Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.