Treating Neurodegenerative Diseases Drug Combination is Key
Synopsis and Key Points:
Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases.
Main DigestCombining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say. Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's,
Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say.
Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's, says Dr. Jerry Buccafusco, founding director of the MCG Alzheimer's Research Center.
"We realize that with neurodegenerative diseases there will not be one magic bullet," Dr. Buccafusco says. "Developing new therapeutics will require an attack on many different levels. But, right now, there are no FDA-approved compounds out there that are significantly disease-modifying. We're at the point where we're just getting to that."
His review of trends in pharmacological research of neurodegenerative diseases is the featured article in the January issue of Neuro-Therapeutics, the journal of the American Society for Experimental Neuro-Therapeutics.
Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase inhibitors, which treat cognition and memory loss, Dr. Buccafusco says.
Dr. Buccafusco also cited several novel drug candidates developed at the MCG Alzheimer's Research Center, including two molecules prevent cell death in the brain and improve cognition, reaction time and attention.
"What we have to do now is look at drugs that have already been developed to address very specific disease targets and come up with new ways to combine constituent groups of active molecules into a single therapeutic agent," Dr. Buccafusco says. "Drugs should target more than one particular molecular structure and molecular receptor in the central nervous system. The technology is available to design molecules that have multiple properties all in one package. This approach could represent a new frontier for pharmacology."
Advantages to multi-functional drug compounds, he says, include fewer side effects.
- 1 - Brain Games or Training Have No Effect On Decision Making or Cognitive Function : University of Pennsylvania School of Medicine (2017/07/10)
- 2 - Course of Human Evolution Could Change With Gene Editing Technology : Issues in Science and Technology (2016/04/07)
- 3 - Candida Yeast Infection and Mental Illness Link : Johns Hopkins Medicine (2016/05/05)
- 4 - Studying Chromosomes Centers May Reveal Link to Down Syndrome : Michigan Medicine - University of Michigan (2017/11/20)
- 5 - Chagas Disease T. cruzi and Dogs : Emory University (2010/07/12)
- 6 - Potential New Causes for TMAU - A Fishy Smelling Body Odor Disorder : Monell Chemical Senses Center (2017/02/15)
- 7 - Hope for Patients with Friedreich's Ataxia and Related Diseases : University of California, Davis (2017/06/08)
• Disabled World is strictly a news and information website provided for general informational purpose only and does not constitute medical advice. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World.
• Please report outdated or inaccurate information to us.