Skip to main content
• Social Media: Connect with UsAccessibility  |  About  |  Contact  |  Privacy  |  Terms

Treating Neurodegenerative Diseases Drug Combination is Key

  • Published: 2009-01-31 : Neurotherapeutics.
  • Synopsis: Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases.

Main Document

Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say. Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's,

Combining the benefits of multiple drugs in a single pill may hold the key to treating neurodegenerative diseases, Medical College of Georgia researchers say.

Drugs that protect neurons, for example, can be used with those targeting memory to make real progress in treating diseases such as Alzheimer's, says Dr. Jerry Buccafusco, founding director of the MCG Alzheimer's Research Center.

"We realize that with neurodegenerative diseases there will not be one magic bullet," Dr. Buccafusco says. "Developing new therapeutics will require an attack on many different levels. But, right now, there are no FDA-approved compounds out there that are significantly disease-modifying. We're at the point where we're just getting to that."

His review of trends in pharmacological research of neurodegenerative diseases is the featured article in the January issue of Neuro-Therapeutics, the journal of the American Society for Experimental Neuro-Therapeutics.

Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase inhibitors, which treat cognition and memory loss, Dr. Buccafusco says.

Dr. Buccafusco also cited several novel drug candidates developed at the MCG Alzheimer's Research Center, including two molecules prevent cell death in the brain and improve cognition, reaction time and attention.

"What we have to do now is look at drugs that have already been developed to address very specific disease targets and come up with new ways to combine constituent groups of active molecules into a single therapeutic agent," Dr. Buccafusco says. "Drugs should target more than one particular molecular structure and molecular receptor in the central nervous system. The technology is available to design molecules that have multiple properties all in one package. This approach could represent a new frontier for pharmacology."

Advantages to multi-functional drug compounds, he says, include fewer side effects.

Similar Topics

1 - Effects of Genetic Engineering - Disabled World.
2 - Majority in Favor of Spinal Muscular Atrophy (SMA) Screening - University of Warwick.
3 - New Approach to Studying Chromosomes' Centers May Reveal Link to Down Syndrome and More - Michigan Medicine - University of Michigan.
4 - Drinking Glasses Can Contain Potentially Harmful Levels of Lead and Cadmium - University of Plymouth.
5 - Brain Training and Brain Games Have No Effect On Decision Making or Cognitive Function - University of Pennsylvania School of Medicine.
From our Medical Research section - Full List (158 Items)

Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.



1 - wheelAIR Innovative New Cooling Wheelchair Backrest Wins Support on Dragons Den
2 - DIVAS Rule the Runway at The Woodlands
3 - Ultra-thin Optical Fibers Provide Way to Print 3D Microstructures
4 - Brain Imaging Predicts Language Learning in Deaf Children
5 - Asthma Costs US Economy Over $80 Billion a Year



Citation


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.