Skip to main content
Accessibility|Contact|Privacy|Terms of Service

First US Trial of Bone-marrow Stem Cells for Heart Attack Patients Proves Safe

  • Published: 2010-09-14 : Author: Minneapolis Heart Institute Foundation
  • Synopsis: Adult stem cells derived from a patient bone marrow presents a potential new type of therapy to benefit individuals after a heart attack.

Main Document

The first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction (STEMI; severe heart attack) demonstrated a strong safety profile for this cell therapy, based on phase 1 results published in the September issue of the American Heart Journal.

"The use of adult stem cells, derived from the patient's own bone marrow, presents a potential new type of therapy to benefit individuals after they suffer a heart attack," says the study's principal investigator Jay H. Traverse, MD, cardiologist at the Minneapolis Heart Institute® at Abbott Northwestern Hospital in Minneapolis, Minn. "Also, these types of stem cells do not possess any of the ethical concerns of embryonic stem cell research."

"While the objective of phase 1 clinical trials is to assess safety, researchers also look for hints of efficacy that have been revealed in previous studies," says Traverse. "Based on indications of some improvements in various European studies, we sought to examine whether this therapy could improve ejection fraction at six months, and whether it had an effect on attenuating adverse left ventricular remodeling as measured by cardiac MRI."

In this single-center trial, the researchers enrolled 40 patients with STEMI, randomizing them in a 3:1 ratio to 100 million autologous BMCs versus placebo, administered three to ten days following successful primary angioplasty and stenting of the left anterior descending coronary artery. Importantly, the researchers elected to deliver cells by an intracoronary infusion as opposed to the stop-flow technique that had been used in all preceding trials and all patients received an identical number of cells.

Administration of BMC was safely performed in all patients with minimal major adverse clinical event rates, and all patients remain alive to date, Traverse and colleagues reported.

While the BMC cell therapy was associated with a significant improvement in left ventricular ejection fraction at six months (49% to 55.2%), the study failed to demonstrate that the cell therapy was superior to placebo because of the similar improvement in the small placebo group (48.6% to 57%). However, the BMC group experienced a significant improvement in left-ventricular volumes at six months compared with the placebo group.

"A review of the available clinical literature reveals a split in the benefit of left ventricular ejection fraction some studies show no benefit and others show a small improvement," Traverse explains. "Any number of factors can influence this outcome: the way the ejection fraction is measured, the timing of BMC administration, how many cells are delivered, the type of STEMI patient population. There are a lot of variables, leading some to question whether ejection fraction is the most appropriate endpoint for cell therapy trials."

"To this point, no study has been properly powered to assess the appropriate timing of BMC administration after a heart attack," says Traverse.

However, Traverse and his colleagues at the Minneapolis Heart Institute® are involved with the TIME trial, sponsored by the National Heart, Lung and Blood Institute's Cardiovascular Cell Therapy Research Network (CCTRN), which is randomizing patients to BMCs at three or seven days post-STEMI to determine the most appropriate timing to administer the stem cells following a heart attack.

This study was supported by the Jon H. Dehaan Foundation. Cell processing was supported by the Production Assistance for Cellular Therapies. The infusion catheters were supplied by Boston Scientific, headquartered in Natick, Mass.

Minneapolis Heart Institute® - The Minneapolis Heart Institute® is recognized internationally as one of the world's leading providers of heart and vascular care. This state-of-the-art facility combines the finest in personalized patient care with sophisticated technology in a unique, family-oriented environment. The Institute's programs, a number of which are conducted in conjunction with Abbott Northwestern Hospital, address the full range of heart and vascular health needs: prevention, diagnosis, treatment and rehabilitation.

Minneapolis Heart Institute Foundation - The Minneapolis Heart Institute Foundation is dedicated to creating a world without heart disease through groundbreaking clinical research and innovative education programs. MHIF's mission is to promote and improve cardiovascular health, quality of life and longevity for all.

Similar Topics

1 : Smart Cells Releases 1st Sample to Treat Autism : Smart Cells.
2 : Discovery May Result in Medication to Build Stronger Muscles Even in Old Age : Karolinska Institutet.
3 : Sensory Interneurons from Stem Cells Enable the Sense of Touch : University of California - Los Angeles Health Sciences.
4 : COPD Patients See Improvement from Stem Cell Therapy : Lung Institute.
5 : Stem Cell Therapy to Relieve Joint Pain : Dr. Mark Wagner.
From our Regenerative Medicine section - Full List (94 Items)


Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





1 : Autism Prevalence Increases to 1 in 59 US Children
2 : Yelp Reviews of Nursing Homes Tend to Focus on Staff Attitudes and Responsiveness
3 : Non-Invasive Spinal Stimulation Enables Paralyzed People to Regain Use of Hands
4 : What if You Could Know Your Mild Cognitive Impairment Would Not Progress?
5 : Millennials Fail to Understand Dangers of Tanning
6 : Appetite Loss After Exercising Explained
7 : Bias Keeps Women with Higher Body Weight Away From the Doctor
8 : Smart Hoteliers are Building a Healthier Future


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.

© 2004 - 2018 Disabled World™