Screen Readers Skip to Content

Hope in New Treatment for Spinal Cord Injuries

Published : 2011-05-04 - Updated : 2016-06-13
Author : Rutgers University

Synopsis* : Chemically synthesized siRNA molecule decreases production of the RhoA protein when administered to the spine and allows regeneration of nerve cells.

Main Digest

Rutgers researchers have developed an innovative new treatment that could help minimize nerve damage in spinal cord injuries, promote tissue healing and minimize pain.

After a spinal cord injury there is an increased production of a protein (RhoA) that blocks regeneration of nerve cells that carry signals along the spinal cord and prevents the injured tissue from healing.

Scientists at the W.M. Keck Center for Collaborative Neuroscience and Quark Pharmaceuticals Inc. have developed a chemically synthesized siRNA molecule that decreases the production of the RhoA protein when administered to the spine and allows regeneration of the nerve cells.

"It is exciting because this minimally-invasive treatment can selectively target the injured tissue and thereby promote healing and reduce pain," says Martin Grumet, associate director of the Keck Center and senior author of a recent study published in the Journal of Neurotrauma.

The neuropathic pain, also known as phantom pain that occurs as a result of a spinal cord injury is often associated with an increased production of RhoA.

When researchers injected the chemically synthesized molecular substance into the spinal cords of laboratory rats with spinal cord injury using a procedure similar to a spinal tap, there was an overall improvement in tissue healing and recovery.

More than 250,000 people in the United States are living with a spinal cord injury and currently there is no way to reverse the damage.

No drugs for early treatment of spinal cord injury have been approved in over a decade.

Based on this joint research, Quark Pharmaceuticals, Inc now has a drug development program for the treatment of spinal cord injury and neuropathic pain.

This new research is supported by grants from the New Jersey Commission for Spinal Cord Research and Quark.

You're reading Disabled World. Be sure to check out our homepage for informative disability news, reviews, sports, stories and how-tos. You can also connect with us on social media such as Twitter and Facebook or learn more about Disabled World on our about us page.

*Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.

Cite Page: Journal: Disabled World. Language: English (U.S.). Author: Rutgers University. Electronic Publication Date: 2011-05-04 - Revised: 2016-06-13. Title: Hope in New Treatment for Spinal Cord Injuries, Source: <a href=https://www.disabled-world.com/disability/types/spinal/rhoa.php>Hope in New Treatment for Spinal Cord Injuries</a>. Retrieved 2021-05-16, from https://www.disabled-world.com/disability/types/spinal/rhoa.php - Reference: DW#248-7568.