Skip to main content

Asymptomatic Atherosclerosis and Cognitive Disability Link

  • Published: 2014-11-25 : Radiological Society of North America (Linda Brooks - lbrooks@rsna.org).
  • Synopsis: Study results reveal importance of identifying early stage atherosclerosis to help preserve heart, cognition and brain health
Atherosclerosis

Also known as arteriosclerotic vascular disease or ASVD, is a specific form of arteriosclerosis in which an artery wall thickens as a result of invasion and accumulation of white blood cells (WBCs). Atherosclerosis is therefore a syndrome affecting arterial blood vessels due to a chronic inflammatory response of WBCs in the walls of arteries. This is promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL). It is commonly referred to as a "hardening" or furring of the arteries. It is caused by the formation of multiple atheromatous plaques within the arteries.

Main Document

Quote: "Atherosclerosis is a condition in which fat, cholesterol and other substances collect in the arteries, forming a substance called plaque that can build up, limiting blood flow."

In a study of nearly 2,000 adults, researchers found that a buildup of plaque in the body's major arteries was associated with mild cognitive impairment. Results of the study conducted at the University of Texas (UT) Southwestern Medical Center will be presented next week at the annual meeting of the Radiological Society of North America (RSNA).

"It is well established that plaque buildup in the arteries is a predictor of heart disease, but the relationship between atherosclerosis and brain health is less clear," said Christopher D. Maroules, M.D., radiology resident at UT Southwestern Medical Center in Dallas. "Our findings suggest that atherosclerosis not only affects the heart but also brain health."

Atherosclerosis is a condition in which fat, cholesterol and other substances collect in the arteries, forming a substance called plaque that can build up, limiting blood flow. It can occur in any artery of the body, including the carotid, which supplies blood to the brain, coronary arteries and the aorta, which carries oxygenated blood from the heart through the abdomen to the rest of body.

In the study, researchers analyzed the test results of 1,903 participants (mean age, 44 years) in the Dallas Heart Study, a multi-ethnic population-based study of adults from Dallas County, Texas. The participants included both men and women who had no symptoms of cardiovascular disease.

Study participants completed the Montreal Cognitive Assessment (MoCA), a 30-point standardized test for detecting mild cognitive impairment, and underwent magnetic resonance imaging (MRI) of the brain to identify white matter hyper-intensity (WMH) volume. Bright white spots known as high signal intensity areas on a brain MR images indicate abnormal changes within the white matter.

"Increased white matter hyper-intensity volume is part of the normal aging process," Dr. Maroules explained. "But excessive WMH volume is a marker for cognitive impairment."

Study participants also underwent imaging exams to measure the buildup of plaque in the arteries in three distinct vascular areas of the body: MRI to measure wall thickness in the carotid arteries and the abdominal aorta, and computed tomography (CT) to measure coronary artery calcium, or the amount of calcified plaque in the arteries of the heart.

Using the results, researchers performed a statistical regression to correlate the incidence of atherosclerosis and mild cognitive impairment. After adjusting for traditional risk factors for atherosclerosis - including age, ethnicity, male sex, diabetes, hypertension, smoking and body mass index - they found independent relationships between atherosclerosis in all three vascular areas of the body and cognitive health, as measured by MoCA scores and white matter hyper-intensity volume on MR images.

Individuals in the highest quartile of internal carotid wall thickness were 21 percent more likely to have cognitive impairment as measured by a low MoCA score. An increasing coronary artery calcium score was predictive of large white matter intensity volume on MRI.

"These results underscore the importance of identifying atherosclerosis in its early stages, not just to help preserve heart function, but also to preserve cognition and brain health," Dr. Maroules said.

Dr. Maroules said the MRI and CT imaging techniques provide valuable prognostic information about an individual's downstream health risks.

"Plaque buildup in blood vessels throughout the body offers us a window into brain health," he said. "Imaging with CT and MRI has an important role in identifying patients who are at a higher risk for cognitive impairment."

For patient-friendly information on MRI and CT, visit RadiologyInfo.org

Co-authors on the study are Jarett Berry, M.D., Amit Khera, M.D., Heidi Rossetti, Ph.D., Kirstine Carter, Ph.D., Mohit K. Gupta, M.D., Ronald M. Peshock, M.D., Roderick McColl, Ph.D., Colby Ayers, M.S., Nagina Malguria, M.B.B.S., Suhny Abbara, M.D., and Kevin S. King, M.D.

Related Information:

  1. Cholesterol Level Chart - Definition of cholesterol including ways to lower cholesterol levels in the blood and includes a cholesterol level chart.
  2. Non-stick Cookware May be Associated with Elevated Cholesterol - JAMA and Archives Journals - (2010-09-06)
    https://www.disabled-world.com/health/cardiovascular/cholesterol/cookware.php
  3. New Cholesterol Guidelines Reveal Most Seniors Qualify for Statin Therapy - Minneapolis Heart Institute Foundation - (2014-11-24)
    https://www.disabled-world.com/health/cardiovascular/cholesterol/statin-therapy.php


Information from our Cognitive Disability: Information on Intellectual Disabilities section - (Full List).

Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





  1. New Peer-reviewed Journal 'Autism in Adulthood' Launching in 2019
  2. People Want to Live Longer - But Only If in Good Health
  3. Canada's Aging Population Signals Need for More Inclusive, Accessible Transportation System
  4. Britain's Unproductive Disabled: A Continuing Moral Panic?

Citation



Disclaimer: Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.