Skip to main content

Leptin-based Weight-loss Pill to Control Hunger Proven to Work

  • Synopsis: Published: 2010-01-26 - Pill composed of leptin tells brain to stop eating proven appetite suppressant when administered intravenously to obese - University of Montreal.

Main Document

A gimmick-free weight-loss pill in the works - University of Montreal research team developing leptin-based pill to control hunger.

A University of Montreal research team is developing a pill composed of leptin, the protein that tells our brain to stop eating. "Mice deprived of leptin will not stop eating. They become so big they have trouble moving around," says Moase Bendayan, a pathology professor at the University of Montreal Faculty of Medicine who has studied the leptin protein extensively.

Leptin regulates appetite in mammals and its levels decrease when fasting and rise during meals. It has been proven to be an appetite suppressant when administered intravenously to pathologically obese people.

Postdoctoral student Philippe Cammisotto is leading the charge for a leptin-based, appetite suppressing pill with Dr. Bendayan and Emile Levy, a professor from the Department of Nutrition. "Taken orally, such a pill would provide obese people with the sensation of being full. They would eat less and in turn lose weight," says Dr. Cammisotto.

"We hope to start animal testing in 2010," says Bendayan. "The molecule is easy to synthesize and the protocol is ready."

After decades of building his reputation in fundamental research, Bendayan is happy to collaborate on something more tangible. "Obesity is a big problem in our society, no pun intended," says Bendayan. "To develop medication to combat obesity would be a great way for our laboratory to contribute to public health."

The new pill is being created based on a startling Universite de Montreal discovery from 2006: leptin isn't only secreted by fatty tissues. "From the first bite of any meal, leptin levels skyrocket in the bloodstream. Yet this has nothing to do with the leptin stored in the fatty tissues," says Bendayan. "In the lab, we proved that up to 80 percent of cells in our stomach also produce leptin. Those are the ones that regulate appetite."

The University of Montreal finding led to a different understanding of how the protein works, since leptin alone can't survive in an acidic stomach without assistance. Indeed, leptin protects itself with an accomplice that acts as its bodyguard and accompanies the protein through the digestive system until it can be absorbed into the bloodstream.



Information from our Dieting: Diets & Diet Plans for Weight Loss section - (Full List).

E-Newsletter

Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be. Also see information on blood group types and compatibility.


  1. Majority in Favor of Spinal Muscular Atrophy (SMA) Screening
  2. When the Spinal Cord Takes Charge of Information Related to Movement
  3. Sign Language Comparative List of Astronomical Words
  4. Israeli President Honors Special Education Teachers




Citation



Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.

Disclaimer: Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.