Skip to main content
Accessibility  |  Contact  |  Privacy  |  Terms of Service

Bortezomib Promising Treatment for Rheumatoid Arthritis

  • Published: 2010-11-04 : Author: Wiley-Blackwell
  • Synopsis: Study suggests biologic drug bortezomib (Velcade) may represent a promising treatment for rheumatoid arthritis.

Main Document

Study finds bortezomib to be promising treatment for rheumatoid arthritis - Proteasome inhibitor reduces inflammation and promotes bone healing in arthritis models.

A new study by Greek researchers suggests that the biologic drug bortezomib (Velcade), a proteasome inhibitor used to treat multiple myeloma (bone marrow cancer), may represent a promising treatment for rheumatoid arthritis (RA). In this study, bortezomib displayed favorable effects in an animal model of inflammatory arthritis that mimics RA, in reducing disease severity and inflammation, and promoting bone healing. Full findings of this study are published in the November issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR).

RA is a chronic, systemic, autoimmune disease characterized by inflammation and joint destruction. The newer biologics, such as the tumor necrosis factor (TNF) inhibitors and monoclonal antibodies, have increased the therapeutic options for patients with RA. However, studies have shown that more than 50% of patients treated with a TNF inhibitor do not meet the ACR 50 improvement criteria a standard set of measures developed by the college to determine efficacy of drugs in clinical trials.

"The definitive role of biologic agents in treating this difficult-to-cure population has yet to be defined in prospective trials comparing the available therapeutic options," explained study leader Evangelia Yannaki, M.D., of George Papanicolaou Hospital in Thessaloniki, Greece. "Given the lack of options for poor responders and the increased risk of infections and malignancies with available biologic agents for RA, there is a great need for novel therapies that are safe and effective."

The research team explored bortezomib as an optimal treatment for RA because the drug targets multiple pathways. In RA, the most important pro-inflammatory mediators are regulated by the transcription factor NF-KB proteins that control genes involved in inflammation and the immune response to infection. Where bortezomib inhibits NF-KB, researchers speculate that the drug may improve autoimmune conditions, such as RA, which are characterized by chronic inflammation.

The analysis demonstrated that in vitro, bortezomib significantly reduced proliferation and increased death of the inflammatory cells in rats with adjuvant induced arthritis (AIA), thereby reducing invasiveness of fibroblast-like cells that are responsible for the damage to the lining of the joints; it also modified the pattern of protein cell signaling (cytokine secretion) in T-lymphocytes that are involved in the immune system response. In vivo, bortezomib significantly improved clinical manifestations of arthritis in these animals, even when administered during the advanced disease phase. Researchers noted that joints in animals treated with the drug displayed limited damage and inflammation, and an obvious bone healing effect was observed.

"Our research showed that bortezomib is a useful treatment in targeting critical cell populations involved in the development of inflammation and autoimmunity in RA," concluded Dr. Yannaki. "We believe that bortezomib should be further explored in a clinical setting, as it represents an attractive intervention for inflammatory conditions and a highly promising agent in the treatment of RA."

Article: "The Proteasome Inhibitor Bortezomib Drastically Affects Inflammation and Bone Disease in a Rat Model of Adjuvant-Induced Arthritis." Evangelia Yannaki, Anastasia Papadopoulou, Evangelia Athanasiou, Panayotis Kaloyannidis, Argyro Paraskeva, Dimitris Bougiouklis, Panayotis Palladas, Minas Yiangou, and Achilles Anagnostopoulos. Arthritis & Rheumatism; Published Online: October 29, 2010 (DOI: 10.1002/art.27690); Print Issue Date: November 2010.

This study is published in the November issue of Arthritis & Rheumatism. Media wishing to receive a PDF of the article may contact

About the Journal - Arthritis & Rheumatism is an official journal of the American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP), a division of the College, and covers all aspects of inflammatory disease. The American College of Rheumatology ( is the professional organization who share a dedication to healing, preventing disability, and curing the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones. Members include practicing physicians, research scientists, nurses, physical and occupational therapists, psychologists, and social workers. For details, please visit

About Wiley-Blackwell - Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit or our new online platform, Wiley Online Library (, one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Similar Topics

1 : Bacteria in Milk and Beef May Be Linked to Rheumatoid Arthritis : University of Central Florida.
2 : Rheumatoid Arthritis and Chikungunya Virus Share Symptoms : Washington University School of Medicine.
3 : Rheumatoid Arthritis: New Effective and Cheaper Treatment : KU Leuven.
4 : Medical Marijuana not Recommended for Rheumatoid Arthritis, Lupus, or Fibromyalgia Symptoms : Wiley.
5 : Shoulder Replacement in Rheumatoid Arthritis Patients : Mayo Clinic.
From our Rheumatoid Arthritis section - Full List (38 Items)

Submit disability news, coming events, as well as assistive technology product news and reviews.

Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.

Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.

List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.

Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.

1 : How Often Do Medical Problems Lead to Bankruptcy?
2 : Videocamp Launches $400,000 Fund and Challenges Filmmakers to Create a Film About Inclusive Education
3 : vEAR: Why Can I Sometimes 'Hear' Silent Flashes When Viewing Animated Gif's?
4 : New Jersey Digital Art Program for Individuals with ASD
5 : 2018 Lime Connect Fellowship Program for Students with Disabilities


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.