Anti-cancer Effects of Natural Alkaloid Extracted from Daffodils

Author: Université libre de Bruxelles
Published: 2018/03/02
Contents: Summary - Main - Related Publications

Synopsis: Study published in the scientific journal Structure describes anti-cancer effects of natural alkaloid extracted from Daffodils.

Main Digest

A study published in the scientific journal Structure (Cell Press) describes the anti-cancer effects of a natural alkaloid extracted from Daffodils.

Led by Denis Lafontaine, affiliated with the Faculty of Sciences at the ULB, the researchers have discovered that this compound triggers the activation of an anti-tumoral surveillance pathway.

Will Daffodils soon help curing cancer?

A study from the RNA Molecular Biology Laboratory (Faculty of Sciences and ULB-Cancer Research Center), published in the scientific journal Structure (Cell Press), took a first step in that direction.

Continued below image.
Picture of ribosome - Image Credit: D. Lafontaine - ULB.
Picture of ribosome - Image Credit: D. Lafontaine - ULB.
Continued...

Led by Denis Lafontaine, the researchers extracted a natural anti-cancer compound from Daffodils (Amaryllidaceae Narcissus).

They established that this compound, an alkaloid named haemanthamine, binds to the ribosome.

Ribosomes are nanomachines essential to the survival of our cells because they synthesize all our proteins.

To sustain their unrestrained growth, cancer cells rely on increased protein synthesis: they are therefore particularly sensitive to treatments that inhibit the production and the function of ribosomes.

In this new study, the researchers have shown that haemanthamine blocks the production of protein by ribosomes, thus slowing growth of cancer cells.

Haemanthamine also inhibits the production of these nanomachines in the nucleolus (the "ribosome factory"): this nucleolar stress triggers the activation of an anti-tumoral surveillance pathway leading to the stabilization of the protein p53 and to the elimination of cancer cells.

This study provides for the first time a molecular explanation to the anti-tumoral activity of Daffodils used for centuries in folk medicine.

Haemanthamine belongs to a large family of therapeutic molecules of natural origin: numerous other alkaloids, used in human health, are extracted from plants, such as morphine (potent pain killer), quinine (anti-malarial agent), and ephedrine (anti-asthmatic).

In a near future, the team of Denis Lafontaine, in collaboration with Veronique Mathieu (Faculty of Pharmacy- ULB), will test the effect on ribosome biogenesis and function of four Amaryllidaceae alkaloids, representative of the chemical diversity of these molecules. Their goal will be to identify rapidly the most promising chemical backbone to be further developed as a lead compound in cancer therapeutics.

Attribution/Source(s):

This quality-reviewed publication pertaining to our Treatment of Cancer section was selected for circulation by the editors of Disabled World due to its likely interest to our disability community readers. Though the content may have been edited for style, clarity, or length, the article "Anti-cancer Effects of Natural Alkaloid Extracted from Daffodils" was originally written by Université libre de Bruxelles, and submitted for publishing on 2018/03/02. Should you require further information or clarification, Université libre de Bruxelles can be contacted at the ulb.ac.be website. Disabled World makes no warranties or representations in connection therewith.

📢 Discover Related Topics


👍 Share This Information To:
𝕏.com Facebook Reddit

Page Information, Citing and Disclaimer

Disabled World is an independent disability community founded in 2004 to provide disability news and information to people with disabilities, seniors, their family and/or carers. You can connect with us on social media such as X.com and our Facebook page.

Cite This Page (APA): Université libre de Bruxelles. (2018, March 2). Anti-cancer Effects of Natural Alkaloid Extracted from Daffodils. Disabled World. Retrieved April 16, 2024 from www.disabled-world.com/health/cancer/treatment/haemanthamine.php

Permalink: <a href="https://www.disabled-world.com/health/cancer/treatment/haemanthamine.php">Anti-cancer Effects of Natural Alkaloid Extracted from Daffodils</a>: Study published in the scientific journal Structure describes anti-cancer effects of natural alkaloid extracted from Daffodils.

Disabled World provides general information only. Materials presented are never meant to substitute for qualified professional medical care. Any 3rd party offering or advertising does not constitute an endorsement.