Screen Readers Skip to Content

MRSA Infection hVISA Linked to High Mortality

Published : 2010-09-12 - Updated : 2010-09-25
Author : Henry Ford Health System

Synopsis: MRSA infection with reduced susceptibility to potent antibiotic drug vancomycin linked to high mortality.

Main Digest

Gene discovery could yield treatments for nearsightedness.

A MRSA infection with a reduced susceptibility to the potent antibiotic drug vancomycin is linked to high mortality, according to a Henry Ford Hospital study.

Researchers found that patients who contracted a MRSA infection with hetero-resistance, called hVISA, stayed in the hospital longer, were more likely to have the infection return after 90 days, and were twice as likely to die from it after 90 days than patients who do not have hVISA.

The study is being presented Sunday at the 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy in Boston.

"Based on our findings, we recommend that hospitals consider routine testing for hVISA," says Katherine Reyes, M.D., a Henry Ford Hospital Internal Medicine physician and the study's lead author. "It remains controversial how differently we will manage these patients upfront. Close follow-up on these patients to make sure their infection is resolved or controlled may save lives."

MRSA, or Methicillin-resistant Staphylococcus aureus, is a bacterium that is resistant to common antibiotics like penicillin. It can cause skin, bloodstream and surgical wound infections and pneumonia. The majority of infections occur among patients in hospitals or other health care settings, though a growing number of infections are being acquired by otherwise healthy people outside those settings.

MRSA strains can be resistant to many drugs, though they are typically susceptible to the antibiotic vancomycin. MRSA infections are often treated with vancomycin administered intravenously.

The study followed 521 patients with MRSA bloodstream infections who were admitted between January 2006 to September 2009 to Henry Ford, an 805-bed tertiary care hospital, education and research complex in Detroit. These infections were screened for hetero-resistance, and 19 hVISA cases were identified.

Dr. Reyes and researchers then compared characteristics and outcomes of the 19 hVISA patients against 19 non-hVISA patients, eliminating such factors as age, source of infection and level of sickness. The results:

The study was funded by Henry Ford Hospital's Division of Infectious Diseases.

You're reading Disabled World. See our homepage for informative disability news, reviews, sports, stories and how-tos. You can also connect with us on social media such as Twitter and Facebook or learn more about Disabled World on our about us page.

Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.

Cite Page: Journal: Disabled World. Language: English (U.S.). Author: Henry Ford Health System. Electronic Publication Date: 2010-09-12 - Revised: 2010-09-25. Title: MRSA Infection hVISA Linked to High Mortality, Source: <a href=https://www.disabled-world.com/health/mrsa/hvisa.php>MRSA Infection hVISA Linked to High Mortality</a>. Retrieved 2021-06-20, from https://www.disabled-world.com/health/mrsa/hvisa.php - Reference: DW#437-5319.