Music Activates Regions of the Brain Spared By Alzheimer's Disease
Author: University of Utah Health(i) : Contact: healthsciences.utah.edu
Published: 2018-04-27 : (Rev. 2018-05-04)
Synopsis and Key Points:
Researchers at the University of Utah Health looking to the salience network of the brain to develop music based treatments to help alleviate anxiety in patients with dementia.
Ever get chills listening to a particularly moving piece of music? You can thank the salience network of the brain for that emotional joint. Surprisingly, this region also remains an island of remembrance that is spared from the ravages of Alzheimer's disease. Researchers at the University of Utah Health are looking to this region of the brain to develop music-based treatments to help alleviate anxiety in patients with dementia. Their research will appear in the April online issue of The Journal of Prevention of Alzheimer's Disease.
"People with dementia are confronted by a world that is unfamiliar to them, which causes disorientation and anxiety" said Jeff Anderson, M.D., Ph.D., associate professor in Radiology at U of U Health and contributing author on the study. "We believe music will tap into the salience network of the brain that is still relatively functioning."
Previous work demonstrated the effect of a personalized music program on mood for dementia patients. This study set out to examine a mechanism that activates the attentional network in the salience region of the brain. The results offer a new way to approach anxiety, depression and agitation in patients with dementia. Activation of neighboring regions of the brain may also offer opportunities to delay the continued decline caused by the disease.
This is a diagram of brain networks involved in processing attention - Image Credit: Brain Network Lab.
For three weeks, the researchers helped participants select meaningful songs and trained the patient and caregiver on how to use a portable media player loaded with the self-selected collection of music.
"When you put headphones on dementia patients and play familiar music, they come alive," said Jace King, a graduate student in the Brain Network Lab and first author on the paper. "Music is like an anchor, grounding the patient back in reality."
Using a functional MRI, the researchers scanned the patients to image the regions of the brain that lit up when they listened to 20-second clips of music versus silence. The researchers played eight clips of music from the patient's music collection, eight clips of the same music played in reverse and eight blocks of silence. The researchers compared the images from each scan.
The researchers found that music activates the brain, causing whole regions to communicate. By listening to the personal soundtrack, the visual network, the salience network, the executive network and the cerebellar and corticocerebellar network pairs all showed significantly higher functional connectivity.
"This is objective evidence from brain imaging that shows personally meaningful music is an alternative route for communicating with patients who have Alzheimer's disease," said Norman Foster, M.D., Director of the Center for Alzheimer's Care at U of U Health and senior author on the paper. "Language and visual memory pathways are damaged early as the disease progresses, but personalized music programs can activate the brain, especially for patients who are losing contact with their environment."
However, these results are by no means conclusive.
The researchers note the small sample size (17 participants) for this study. In addition, the study only included a single imaging session for each patient. It is remains unclear whether the effects identified in this study persist beyond a brief period of stimulation or whether other areas of memory or mood are enhanced by changes in neural activation and connectivity for the long term.
"In our society, the diagnoses of dementia are snowballing and are taxing resources to the max," Anderson said. "No one says playing music will be a cure for Alzheimer's disease, but it might make the symptoms more manageable, decrease the cost of care and improve a patient's quality of life."
K.G. Jones, M. Rollins, K. Macnamee, C. Moffit, S.R. Naidu, E. Garcia-Leavitt, R.K. Gurgel, J. Amaro and K.R. Breitenbach at U of U Health and University of Utah, E. Goldberg from the Jewish Family Services of Utah, J.M. Watson from University of Colorado and M.A. Ferguson from Massachusetts General Hospital also contributed to this project. This work received support from A. Scott Anderson and the American Otological Society.
(i)Source/Reference: University of Utah Health. Disabled World makes no warranties or representations in connection therewith. Content may have been edited for style, clarity or length.
- 1 - OCTA Eye Scan May Detect Sign of Early Alzheimer's Disease : American Academy of Ophthalmology (2018/11/03)
- 2 - How America Can Cope with Future Alzheimer's Epidemic : Silverado Senior Living (2010/10/19)
- 3 - Music Activates Regions of the Brain Spared By Alzheimer's Disease : University of Utah Health (2018/04/27)
- 4 - Link Between Vitamin D and Alzheimer's Disease : Thomas C. Weiss (2014/08/15)
- 5 - Importance of Family History for Onset of Alzheimer's Disease : McGill University (2018/02/26)
- 6 - New Criteria and Guidelines for the Diagnosis of Alzheimer's Disease : Alzheimer's Association (2011/04/19)
- 7 - DHA Fish Oil Supplements Do Not Slow Cognitive Decline in Alzheimer's : JAMA and Archives Journals (2010/11/03)
• Disabled World is strictly a news and information website provided for general informational purpose only and does not constitute medical advice. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World.
• Please report outdated or inaccurate information to us.