Pleural Mesothelioma Combination Therapy Shows Promise

Author: University of Pennsylvania School of Medicine
Published: 2011/06/09 - Updated: 2025/03/22
Publication Details: Peer-Reviewed, Reports & Proceedings
Topic: Mesothelioma - Publications List

Page Content: Synopsis - Introduction - Main - Insights, Updates

Synopsis: This information provides a comprehensive overview of combination therapy as a treatment approach for mesothelioma, a rare and aggressive cancer. It explains the rationale behind using multiple treatment modalities, such as chemotherapy, surgery, radiation, and emerging targeted therapies, to improve patient outcomes. The article details how these different approaches work synergistically to attack cancer cells through various mechanisms, potentially leading to better tumor control and increased survival rates. This resource could be particularly valuable for individuals diagnosed with mesothelioma, their families, and caregivers, including seniors and those with disabilities who may be seeking accessible and understandable information about their treatment options and the potential benefits of a combined therapeutic strategy - Disabled World (DW).

Introduction

Combination therapy shows promise for rare, deadly cancer caused by asbestos - Photodynamic therapy added to lung-sparing surgery provides superior results for overall survival in mesothelioma patients.

Focus

Pleural mesothelioma patients who undergo lung-sparing surgery in combination with photodynamic therapy (PDT) show superior overall survival than a patient treated using the conventional therapy of extrapleural pneumonectomy (EPP) (or en bloc removal of the lung and surrounding tissue) with PDT, indicates new research from the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania. The research is published in the June 2011 issue of the Annals of Thoracic Surgery.

"Unlike patients who receive traditional lung sacrificing surgery for mesothelioma, the patients in our study who underwent lung-sparing surgery and photodynamic therapy, a light-based cancer treatment, have experienced unusually long overall survival rates. The median survival for those patients was not reached at over two years when the results were analyzed. That's unusual in this field, especially when most of those patients are older and have advanced cancer," said Joseph Friedberg, MD, co-director of the Penn Mesothelioma and Pleural Program and the thoracic surgeon who performed the operations cited in the study.

"In addition to the overall survival statistics, the difference between having and not having a lung, both concerning the risk of surgery and the ability to enjoy a normal life after surgery, is crucial for these patients."

Mesothelioma is one of the most aggressive and deadliest forms of cancer and is usually caused by exposure to asbestos. Exposure to asbestos typically precedes the development of cancer by anywhere from 10 - 50 years, but once it occurs, the average survival rate following diagnosis is often only 9-12 months.

Although mesothelioma can occur in other locations like the abdomen, pleural mesothelioma is the most common disease and accounts for roughly 70 percent of cases. This form originates in the pleura - the membrane surrounding the lung and lining the chest - where it starts off as a microscopic sheet of malignant cells that coats the chest's interior and can grow several inches thick. Cancer's coating and enveloping nature make it impossible to remove it with surgery alone completely. As a result, the conventional surgery-based approach to treatment involves radical surgery that includes removing the lung and chemotherapy and whole chest radiation. Even with this aggressive treatment, the disease will recur in almost all patients.

The current study had two goals.

• The first was to determine if using a new combination of PDT and surgery would allow a less extensive surgical procedure to be used instead of an EPP.
• The second was to determine if, based on previous research from Penn with PDT, the treatment would have any positive effect on survival for patients.

Unlike radiation, which passes through the body, the PDT therapy used in the current study penetrates only a short distance which allows the lung to be preserved. The PDT treatment aims to eradicate the remaining microscopic disease that triggers a patient's immune system to help fight cancer. Penn is one of only two centers in the world where PDT is used to treat pleural mesothelioma.

In the study:

• 28 patients (19 men, nine women) underwent surgical resection plus PDT for pleural mesothelioma.
• Patients were aged from 27 to 81 years.
• All patients were seen in a multidisciplinary setting and educated about the spectrum of treatment options available, including surgical intervention and its current investigational status.
• Of the study group, 14 patients were treated by modified extrapleural pneumonectomy (MEPP) and 14 by radical pleurectomy (RP) and intraoperative PDT.
• Twenty-two of the 28 patients also received chemotherapy.

Demographics in the MEPP and RP cohorts were similar in age, sex, stage, nodal status, histology, and adjuvant treatments.

Stage III/IV disease was present in 12 of 14 patients (86 percent) in both groups.

The median overall survival for the patients who received the MEPP treatment was 8.4 months.

At a follow-up 2.1 years after the end of treatment, a median survival rate for the patients who received a radical pleurectomy had not yet been reached. The results yielded by the radical pleurectomy and adjuvant PDT were superior to other studies of surgical treatment plans with patients of similar demographics.

"Our primary motivation in attempting the lung-sparing surgery was the preservation of quality of life, and we were hoping the survival results would at least be similar to the more traditional pneumonectomy approach," said Friedberg. "Although our pneumonectomy results were in line with what is often reported for similar patients having surgery-based treatments, we were completely caught off guard when the analysis revealed a significantly longer survival for the patients who retained both lungs."

Although all patients in the current study received the PDT therapy in combination with a different surgical technique, the researchers further note that the use of intraoperative PDT is the evident difference between the multimodal protocol used in the current study and other standard treatment options presently in use. It seems worth speculating on any potential direct contributions of the PDT to the overall survival rates.

"Why this is happening is unclear and has emerged as the focus of our continuing research," said Friedberg. The residual PDT-treated microscopic disease possibly induced an autologous tumor vaccine effect or enhanced the effect of adjuvant treatments.

"This study has limitations, as many mesothelioma studies do, but these results are very encouraging. The findings from our study are particularly notable because many of the patients in this study would often be excluded from surgery-based therapy because of their advanced age or unfavorable oncologic characteristics such as the large bulk of their cancers or the spread to the lymph nodes" said Dr. Friedberg. "Based on these results, this lung-sparing technique, combined with photodynamic therapy, has become the backbone of our surgery-based treatment protocols."

A larger study investigating the efficacy of this multimodal approach is currently underway at Penn.

The Penn Mesothelioma and Pleural Program is a unique program with a multidisciplinary team of dedicated specialists with a passion and expertise for treating patients with these difficult cancers. The Penn Program offers a truly multidisciplinary approach, presenting patients with essentially all treatment options offered worldwide, and several treatments offered only at Penn.

Insights, Analysis, and Developments

Attribution/Source(s): This peer reviewed publication was selected for publishing by the editors of Disabled World (DW) due to its relevance to the disability community. Originally authored by University of Pennsylvania School of Medicine and published on 2011/06/09, this content may have been edited for style, clarity, or brevity. For further details or clarifications, University of Pennsylvania School of Medicine can be contacted at pennmedicine.org NOTE: Disabled World does not provide any warranties or endorsements related to this article.