Genital Herpes Virus Reactivates Throughout Genital Tract
Published : 2010-01-23 - Updated : 2020-06-05
Author : The Journal of Infectious Diseases - Contact: idsociety.org
Synopsis* : Study finds the virus can frequently reactivate throughout the genital tract, an important new concept that could help guide both HSV-2 treatment and prevention. Study's findings illustrate important new concept in HSV-2 pathogenesis and may help in developing comprehensive treatment that both suppresses and limits the transmission of HSV-2 infection. Using detailed sampling method and sensitive assay the authors showed both symptomatic and asymptomatic HSV-2 reactivations often occurred at widely spaced regions throughout the genital tract.
Genital herpes caused by a reactivation of herpes simplex virus type 2 (HSV-2) is generally treated as a lesion in one specific area of the genital region.
A new study, however, finds that the virus can frequently reactivate throughout the genital tract, an important new concept that could help guide both HSV-2 treatment and prevention. Now available online, the study appears in the Feb. 15 issue of The Journal of Infectious Diseases.
In the study, Christine Johnston, MD, MPH, and colleagues at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle collected daily samples during a 30-day period from seven separate genital sites in four women infected with HSV-2. HSV-2 was detected from more than one anatomic site on 56 percent of days when there was viral shedding and on genital surfaces on both sides of the participants' bodies on most days when virus was detected at more than one site.
Using a detailed sampling method and a sensitive assay, the authors showed that both symptomatic and asymptomatic HSV-2 reactivations often occurred at widely spaced regions throughout the genital tract. These reactivations were often on both sides of the body, even though clinical lesions typically emanate from one anatomic spot.
The study's findings illustrate an important new concept in HSV-2 pathogenesis, the authors wrote, and may help in developing comprehensive treatment that both suppresses and limits the transmission of HSV-2 infection.
The authors also noted limitations of their study, including a small sample size and the unique features of the study's subjects. For example, all participants had a history of symptomatic genital herpes, and three of the four had acquired HSV-2 infection within the past year, increasing the chances of high viral reactivation and lesion rates. Additionally, although there were a high proportion of days with lesions during the study period, two of the participants who had recently acquired genital herpes contributed the majority of lesion days.
In an accompanying editorial, Edward W. Hook III, MD, of the University of Alabama at Birmingham, called the study's findings "of great potential importance, as they further challenge widely held beliefs regarding genital herpes and, by extension, its management."
Many clinicians treat patients with newly diagnosed herpes episodically, managing the signs and symptoms of periodic symptomatic recurrences, Dr. Hook wrote. "From a personal and public health perspective, the biology of the infection suggests that a national campaign for serological testing of those at risk would provide the foundation for more effective efforts to control HSV transmission to others, and that for most sexually active persons with HSV-2 whose sex partners are not known to also be infected, suppressive therapy should be the preferred approach."
Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. JID is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing more than 9,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org
- Tips to Cure a Yeast Infection
- Herpes Simplex Virus
- Candidiasis Fungal Infection Must be Treated Early
- Yeast Infection Prevention Tips for Physically Challenged
- Candida Yeast Infection and Mental Illness Link
Genital Herpes Virus Reactivates Throughout Genital Tract | The Journal of Infectious Diseases (idsociety.org). Disabled World makes no warranties or representations in connection therewith. Content may have been edited for style, clarity or length.
You're reading Disabled World. Be sure to check out our homepage for further informative disability news, reviews, disability sports events, exclusive stories and how-tos. You can also find us on Twitter, Facebook, and LinkedIn.
Related Herpes Simplex Virus Documents
- 1 - 66% of Population Under 50 Infected with Herpes : WHO global estimate reveals over 3.7 billion people under the age of 50 are infected with herpes simplex virus type 1 (HSV-1).
- 2 - Can You Get Shingles Again : Article looks at whether people that have had Shingles or herpes zoster in the past could have another outbreak.
- 3 - Study Shows Shingles Vaccine is Safe : The herpes zoster vaccine also known as the shingles vaccine is generally safe and well tolerated according to a Vaccine Safety Datalink study.
- 4 - Genital Herpes Vaccine Ineffective in Women : An experimental vaccine intended to prevent genital herpes disease in women although generally safe and well-tolerated proved ineffective.
- 5 - Antiviral Therapy Associated with Fewer Recurring Eye Problems from Herpes Simplex Virus : Taking oral antiviral medications following infection with the herpes simplex virus may be associated with a reduced risk of recurring eye-related manifestations.
*Disclaimer: Disabled World provides general information only. Materials presented are in no way meant to be a substitute for professional medical care by a qualified practitioner, nor should they be construed as such. Any 3rd party offering or advertising on disabled-world.com does not constitute endorsement by Disabled World. View our Advertising Policy for further information. Please report outdated or inaccurate information to us.
Journal: Disabled World. Language: English (U.S.). Author: The Journal of Infectious Diseases. Electronic Publication Date: 2010-01-23 - Revised: 2020-06-05. Title: Genital Herpes Virus Reactivates Throughout Genital Tract, Source: <a href=https://www.disabled-world.com/health/dermatology/herpes/genital-herpes.php>Genital Herpes Virus Reactivates Throughout Genital Tract</a>. Retrieved 2021-05-07, from https://www.disabled-world.com/health/dermatology/herpes/genital-herpes.php - Reference: DW#291-3053.