Skip to main content

Diabetes Drugs for Diabetics with Kidney Disease

  • Synopsis: Published: 2011-11-12 (Revised/Updated 2014-03-14) - Some blood sugar lowering drugs have caused kidney problems in patients Sitagliptin is safer and as effective as glipizide in patients with Type 2 diabetes and chronic kidney disease. For further information pertaining to this article contact: American Society of Nephrology.

Main Document

Quote: "Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage."

Which diabetes drug is best for diabetics with kidney disease- Sitagliptin is safer and as effective as glipizide in patients with Type 2 diabetes and chronic kidney disease.

Sitagliptin is as effective as glipizide at lowering blood sugar levels in patients with type 2 diabetes and chronic kidney disease.

Some blood-sugar-lowering drugs have caused kidney problems in patients with type 2 diabetes, so physicians are especially cautious when prescribing these agents to diabetics who also have chronic kidney disease (CKD).

Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage. New clinical trial results presented during the American Society of Nephrology's Annual Kidney Week compared the two drugs.

Sitagliptin and glipizide act on different targets but generate the same result - they boost the effects of insulin, which lowers blood sugar levels.

Juan Arjona Ferreira, MD, (MSD Corp.) and his colleagues conducted a 54-week study to compare the efficacy and safety of sitagliptin and glipizide in patients with type 2 diabetes and moderate or severe CKD who were not on dialysis. The researchers randomized 426 patients to receive sitagliptin or glipizide.

Among the major findings at the end of the study:

Blood glucose levels dropped to a similar extent in patients in both groups.

Patients receiving sitagliptin were less likely to experience hypoglycemia - or dangerously low blood sugar levels - than patients receiving glipizide (6.2% vs 17.0%).

Patients who took sitagliptin tended to lose a small amount of weight, while most patients who took glipizide experienced a slight weight gain.

Study authors for "Efficacy and Safety of Sitagliptin vs. Glipizide in Patients with Type 2 Diabetes and Moderate to Severe Chronic Renal Insufficiency" (abstract LB-PO3166) include Juan Arjona Ferreira, MD, Michel Marre, MD, PhD, George Bakris, MD, and Ton Rabelink, MD, PhD.

Disclosures: Juan Arjona Ferreira is employed by and has ownership interest in Merck Sharp & Dohme, Corp. Michel Marre receives honoraria from is a scientific adviser for or has other relationships with Abbott, Eli Lilly, MSD, Novo Nordisk, Sanofi Aventis, and Servier. George Bakris has consultancy agreements with CVRx, Relapsya, Johnson & Johnson, Medtronic, Merck, Abbott, Takeda, and Reata; and receives research funding from Novartis, Forest, and Takeda. Ton Rabelink receives speaker fees from Daiichi Sankyo.

ASN Kidney Week 2011, the largest nephrology meeting of its kind, will provide a forum for 13,000 professionals to discuss the latest findings in renal research and engage in educational sessions related to advances in the care of patients with kidney and related disorders. Kidney Week 2011 will take place November 8 - November 13 at the Pennsylvania Convention Center in Philadelphia, PA.

Founded in 1966, and with more than 12,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.



Related Information:

  1. Diabetes Information Type 1 and Type 2 - This guide will help you learn how to take care of your diabetes and how to prevent some of the serious problems that diabetes can cause.


Information from our Diabetes: Types, Symptoms and Treatments section - (Full List).


     What will I receive?

Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be. Also see information on blood group types and compatibility.


  1. New Approach to Studying Chromosomes' Centers May Reveal Link to Down Syndrome and More
  2. Social Mobile Gaming Boosts Rehabilitation for Patients with Physical Disabilities
  3. Rebuilding Spinal Cords with Energetic Polymer Scaffold
  4. Nonprofit Disability Solutions Connects Jobseekers with Top Companies




Citation