Skip to main content
Accessibility|Contact|Privacy|Terms|Cookies

MitoQ Novel Antioxidant Makes Old Arteries Seem Young Again

  • Published: 2018-04-22 : *Press Release by University of Colorado at Boulder : Contact: colorado.edu
  • Synopsis: Seniors who took a novel antioxidant that specifically targets cellular powerhouses, or mitochondria, saw age-related vascular changes reverse by equivalent of 15 to 20 years within 6 weeks.

Quote: "This is the first clinical trial to assess the impact of a mitochondrial-specific antioxidant on vascular function in humans"

Main Document

Older adults who take a novel antioxidant that specifically targets cellular powerhouses, or mitochondria, see age-related vascular changes reverse by the equivalent of 15 to 20 years within six weeks, according to new University of Colorado Boulder research.

MitoQ is a next generation antioxidant that has been derived from CoenzymeQ10. MitoQ is an orally active antioxidant that has the ability to target mitochondrial dysfunction.

MitoQ has been reported to assist those who have a condition associated with higher oxidative stress such as diabetes, obesity, metabolic syndrome, neurodegenerative diseases and cardiovascular disease.

Those taking MitoQ have reported increased energy, a general feeling of wellbeing, clarity of thought, increased libido, decreased perception of pain and a sense of increased exercise endurance.

The study, published this week in the American Heart Association journal Hypertension, adds to a growing body of evidence suggesting pharmaceutical-grade nutritional supplements, or nutraceuticals, could play an important role in preventing heart disease-the nation's No. 1 killer. It also resurrects the notion that oral antioxidants, which have been broadly dismissed as ineffective in recent years, could reap measurable health benefits if properly targeted, the authors say.

"This is the first clinical trial to assess the impact of a mitochondrial-specific antioxidant on vascular function in humans," said lead author Matthew Rossman, a postdoctoral researcher in the department of integrative physiology. "It suggests that therapies like this may hold real promise for reducing the risk of age-related cardiovascular disease."

For the study, Rossman and senior author Doug Seals, director of the Integrative Physiology of Aging Laboratory, recruited 20 healthy men and women age 60 to 79 from the Boulder area.

Half took 20 milligrams per day of a supplement called MitoQ, made by chemically altering the naturally-occurring antioxidant Coenzyme Q10 to make it cling to mitochondria inside cells.

The other half took a placebo.

After six weeks, researchers assessed how well the lining of blood vessels, or the endothelium, functioned, by measuring how much subjects' arteries dilated with increased blood flow.

Then, after a two-week "wash out" period of taking nothing, the two groups switched, with the placebo group taking the supplement, and vice versa. The tests were repeated.

The researchers found that when taking the supplement, dilation of subjects' arteries improved by 42 percent, making their blood vessels, at least by that measure, look like those of someone 15 to 20 years younger. An improvement of that magnitude, if sustained, is associated with about a 13 percent reduction in heart disease, Rossman said. The study also showed that the improvement in dilation was due to a reduction in oxidative stress.

In participants who, under placebo conditions, had stiffer arteries, supplementation was associated with reduced stiffness.

Blood vessels grow stiff with age largely as a result of oxidative stress, the excess production of metabolic byproducts called free radicals which can damage the endothelium and impair its function. During youth, bodies produce enough antioxidants to quench those free radicals. But with age, the balance tips, as mitochondria and other cellular processes produce excess free radicals and the body's antioxidant defenses can't keep up, Rossman said.

Oral antioxidant supplements like vitamin C and vitamin E fell out of favor after studies showed them to be ineffective.

"This study breathes new life into the discredited theory that supplementing the diet with antioxidants can improve health," said Seals. "It suggests that targeting a specific source-mitochondria-may be a better way to reduce oxidative stress and improve cardiovascular health with aging."

The study was funded by the National Institutes of Health. MitoQ Limited provided supplements and some financial support. This summer, Rossman and Seals plan to launch a three-month follow-up study to confirm the findings in a larger number of subjects and look more closely at the impact the compound has on mitochondria. The same lab published another study recently, showing that a compound called nicotinamide riboside may also be able to reverse vascular aging in healthy subjects.

"Exercise and eating a healthy diet are the most well-established approaches for maintaining cardiovascular health," said Seals. "But at the public health level, not enough people are willing to do that. We're looking for complementary, evidence-based options to prevent age-related changes that drive disease. These supplements may be among them."

Discussion

• Have your say! Add your comment or discuss this article on our FaceBook Page.

Similar Topics

1 : MitoQ Novel Antioxidant Makes Old Arteries Seem Young Again : University of Colorado at Boulder.
2 : Mushrooms - Antioxidants and Possible Antiaging Potential : Penn State.
3 : Evidence Reveals Antioxidant Fisetin May Reduce Mental Effects of Aging : Salk Institute.
4 : Maple Syrup Found to Protect Neurons and Nurture Minds : University of Montreal Hospital Research Centre (CRCHUM).
5 : Lipoic Acid: Circadian Rhythms & Biological Function Benefits : Disabled World.
From our Antioxidants section - Full List (25 Items)


Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





1 : Turnstone Center Designated as Official Paralympic Training Site by US Olympic Committee
2 : Help Your Child in School by Adding Language to The Math
3 : 50% of Retirees Saw Little or No COLA Increase in Net 2018 Social Security Benefits
4 : Turnstone Endeavor Games Concludes with National Records Broken
5 : Spinning in Circles and Learning From Myself by Tsara Shelton
6 : St. Louis HELP Medical Equipment Donation Drive Generates Record-Breaking Results
7 : People Who Snore Suffer from Palate Nerve and Muscle Damage
8 : How Our Ancestors with Autistic Traits Led a Revolution in Ice Age Art

*Press Release by University of Colorado at Boulder: Disabled World makes no warranties or representations in connection therewith. If you are connected with this page and want it corrected/updated please contact us.



Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.

© 2004 - 2018 Disabled World™