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Rethinking the Impact of Adolescent Fitness on Future Cardiovascular Health

Author: Karolinska Institutet
Published: 2023/11/17 - Updated: 2023/11/18
Publication Type: Research Study Analysis - Peer-Reviewed: Yes
Topic: Fitness and Nutrition (Publications Database)

Page Content: Synopsis Introduction Main Item

Synopsis: Study findings suggest that for effective CVD prevention, halting and reversing the obesity epidemic should be prioritized.

Many observational studies have previously demonstrated links between various risk factors at a young age and cardiovascular disease in adulthood. However, whether the associations are causal is challenging to prove because of the potential influence of unaccounted genetic and environmental factors.

We also think that adolescence is an important time in life for establishing good habits such as exercising and having a healthy diet.

Introduction

There is a well-known relationship between good physical fitness at a young age and a lower risk of cardiovascular disease later in life. However, when researchers adjusted for familial factors by means of sibling analysis, they found a weaker association, although the link between high body mass index (BMI) and cardiovascular disease remained strong.

Main Item

The study, which was conducted by researchers from Karolinska Institutet and other universities, is published in JAMA Network Open.

"This does not mean that fitness is irrelevant," says the study's last author Viktor Ahlqvist, doctoral student at the Department of Global Public Health, Karolinska Institutet. "We could still see an association, although it was weaker after taking into account factors shared by full siblings. We also think that adolescence is an important time in life for establishing good habits such as exercising and having a healthy diet."

Challenging to Prove Causal Associations

Many observational studies have previously demonstrated links between various risk factors at a young age and cardiovascular disease in adulthood. However, whether the associations are causal is challenging to prove because of the potential influence of unaccounted genetic and environmental factors. A collaborative team including researchers from Karolinska Institutet in Sweden has therefore tried to examine if a large proportion of cardiovascular diseases in adulthood could indeed be prevented with a lower BMI, lower blood pressure, improved physical fitness or improved muscle strength in adolescence.

Sourcing data from the Swedish Military Conscription Register and other Swedish registries, the researchers identified over a million 18-year-old males and followed them for 60 years. Almost half of them were full brothers.

"The strength of our study, which makes it more reliable than many other conventional observational studies, is that we have used sibling analyses," says the study's first author Marcel Ballin, researcher at Uppsala University and analyst at Region Stockholm's Centre for Epidemiology and Community Medicine. "By doing so we could examine how the relationship changes when controlling for all shared sibling factors. This includes environmental factors such as childhood environment and half of the genetics."

High BMI is a Strong Risk Factor

The results show that a high BMI in late adolescence was strongly associated with future cardiovascular disease, even after the researchers had controlled for shared familial factors. However, the association between physical fitness and cardiovascular disease was considerably weaker in the sibling analysis, suggesting that many previous observational studies might have overestimated the relevance of adolescent fitness to cardiovascular health later in life.

"Our conclusion is that of the risk factors studied, high BMI is the strongest individual risk factor for cardiovascular disease, and that efforts to tackle the obesity epidemic should continue to be given high priority," says co-author Daniel Berglind, docent at the Department of Global Public Health, Karolinska Institutet. "A good level of fitness and muscle strength in adolescence doesn't seem as crucial, but physical activity still remains important for public health, as it can bring other health benefits."

Several Limitations

The study examined the association between risk factors at a young age and future cardiovascular disease; other disease outcomes were not investigated. The researchers had no data on whether the participants' risk factors varied later in life, and they only studied men, which makes it difficult to extend their findings to women. The Military Conscription Register also lacks details on certain risk factors for future cardiovascular disease, such as diet, alcohol consumption, smoking, blood lipids and blood glucose.

Publication

The researchers received no specific grant for this study. Co-author Martin Neovius is on the advisory panels for Ethicon, Johnson & Johnson and Itrim and has been a consultant for the Swedish armed forces outside the scope of this study. No other conflicts of interest have been reported.

"Genetic and environmental factors and cardiovascular disease risk in adolescents", Marcel Ballin, Martin Neovius, Francisco B. Ortega, Pontus Henriksson, Anna Nordström, Daniel Berglind, Peter Nordström, Viktor H. Ahlqvist, JAMA Network Open, online 17 November 2023.

Attribution/Source(s):

This peer reviewed publication was selected for publishing by the editors of Disabled World due to its significant relevance to the disability community. Originally authored by Karolinska Institutet, and published on 2023/11/17 (Edit Update: 2023/11/18), the content may have been edited for style, clarity, or brevity. For further details or clarifications, Karolinska Institutet can be contacted at ki.se. NOTE: Disabled World does not provide any warranties or endorsements related to this article.

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Cite This Page (APA): Karolinska Institutet. (2023, November 17 - Last revised: 2023, November 18). Rethinking the Impact of Adolescent Fitness on Future Cardiovascular Health. Disabled World. Retrieved December 12, 2024 from www.disabled-world.com/fitness/fitness-impact.php

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