Skip to main content
Accessibility|Contact|Privacy|Terms of Service

Human Embryonic Stem Cells Source of Oral Mucosal Tissues

  • Published: 2009-04-04 : Author: International & American Association for Dental Research
  • Synopsis: Human embryonic stem cells provide unlimited source of oral mucosal tissues that may revolutionize the treatment of oral diseases.

Main Document

Human embryonic stem cells (hESC) provide a potentially unlimited source of oral mucosal tissues that may revolutionize the treatment of oral diseases.

Human embryonic stem cells (hESC) provide a potentially unlimited source of oral mucosal tissues that may revolutionize the treatment of oral diseases.

When fully exploited in the future, this source of cells will be able to produce functional tissues to treat a broad variety of oral diseases. However, little is known about how hESC can be developed into complex, multilayer oral tissues that line the gums, cheeks, lips, and other intra-oral sites. However, the use of hES cells for oral application faces numerous obstacles that must be overcome before their therapeutic potential can be realized.

Today, during the 87th General Session of the International Association for Dental Research, investigators from Tufts University in Boston report on their research to optimize the potential of hESC cells to generate complex, functional multilayer tissues, such as the oral mucosa and skin, and to understand how tissue fabrication is controlled and directed.

The Garlick lab has used tissue engineering principles to produce complex oral-lining tissues that mimic many features of their counterparts found in the oral cavity. Making these tissues was a two-step process. With a combination of chemical signals and specialized surfaces on which these cells attach, an hESC cell line (H9) was directed toward two divergent cell populations. The first population comprises the surface layer (epithelial cells) of complex tissues, while the other is found beneath these cells (mesenchymal cells). Following their isolation and characterization, the team incorporated these two distinct cell populations into the two tissue compartments that comprise these tissue types. The populations were then grown at an air-liquid interface to mimic their growth environment in the oral cavity. Within two weeks, tissues developed that shared many features in common with normal tissues that were constructed with mature cells that are the "gold standard" of normal tissue generation in our lab.

For the first time, researchers have established proof of concept that a single, common source of pluripotent hESC could provide the multiple cell types needed to be recombined within different, but interactive, tissue compartments to generate complex, multilayer tissues. In addition to providing oral mucosal tissues for future transplantation, the tissues generated in these studies can now be used to answer questions regarding the stability and safety of hESC-derived cells and tissues by providing information that will predict how they will respond after therapeutic transplantation in the future.

Reference: This is a summary of abstract #3021, "Microenvironmental Cues Direct 3D Tissues from Human Embryonic Stem Cells", by J. Garlick et al. of Tufts University (Boston, Mass., USA), to be presented at 11:45 a.m. on Saturday, April 4, 2009, in Room D235 of the Miami Beach Convention Center, during the 87th General Session of the International Association for Dental Research.

Similar Topics

1 : Smart Cells Releases 1st Sample to Treat Autism : Smart Cells.
2 : Discovery May Result in Medication to Build Stronger Muscles Even in Old Age : Karolinska Institutet.
3 : Sensory Interneurons from Stem Cells Enable the Sense of Touch : University of California - Los Angeles Health Sciences.
4 : COPD Patients See Improvement from Stem Cell Therapy : Lung Institute.
5 : Stem Cell Therapy to Relieve Joint Pain : Dr. Mark Wagner.
From our Regenerative Medicine section - Full List (94 Items)


Submit disability news, coming events, as well as assistive technology product news and reviews.


Loan Information for low income singles, families, seniors and disabled. Includes home, vehicle and personal loans.


Famous People with Disabilities - Well known people with disabilities and conditions who contributed to society.


List of awareness ribbon colors and their meaning. Also see our calendar of awareness dates.


Blood Pressure Chart - What should your blood pressure be, and information on blood group types/compatibility.





1 : Telemedicine Helps Overcome Healthcare Gender Based Barriers
2 : Screen Reader Plus Keyboard Helps Blind, Low-Vision Users Browse Modern Webpages
3 : Our Digital Remains Should be Treated with Same Care and Respect as Physical Remains
4 : Tungsten: Concern Over Possible Health Risk by Human Exposure to Tungsten
5 : Student Loan Discharge Process for Disabled Veterans Made Easier
6 : Growing Bone and Cartilage Tissues for Humans from Flaxseed Like Particles
7 : Throat Reflexes Differ in People with Tetraplegia and Sleep Apnea
8 : UTA Grant to Help Minority Students Link Assistive Technology with Disability Studies
9 : Body Probe as Thin as a Hair Has Imaging Function and Temperature Sensor
10 : Dripping Candle Wax Bone Disease (Melorheostosis) Cause Solved


Disclaimer: This site does not employ and is not overseen by medical professionals. Content on Disabled World is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. See our Terms of Service for more information.

Reporting Errors: Disabled World is an independent website, your assistance in reporting outdated or inaccurate information is appreciated. If you find an error please let us know.

© 2004 - 2018 Disabled World™